A list of five scientific theories that were accepted and later disproved

The history of blood, as told by a hematologist

Since ancient times, blood has been seen as a semi-magical substance. Alchemists theorized it was a mixture of the four elements. Others proposed it was one of four bodily fluids whose balance dictated health. This 2019 essay by a hematologist reviews blood's reputation across cultures and centuries.

The history of germ theory, which explains that illnesses are caused by microorganisms

For centuries, the miasma theory, which held that illnesses were caused by clouds of "bad air" produced by decaying organic matter, was the accepted explanation for the spread of disease. The development of microscopes and the subsequent technology to isolate bacteria and test disease spread in mice greatly contributed to contagionists overturning miasmatists.

Why being able to disprove explanations distinguishes scientific theories from pseudoscience

Introduced by philosopher Karl Popper, falsifiability holds that a scientific theory must make predictions that could be proven inaccurate by future observations. Explanations that cannot make such predictions are not scientific theories. It is scientists' jobs to seek out data to poke holes in scientific theories, thereby potentially strengthening them if they hold up to scrutiny.

Learn why modern scientific patterns have been described as theories rather than laws

After confirming that the accuracy of some laws of physics is limited to certain domains, science became more hesitant to categorize identified mathematical relationships, such as quantum mechanics, as unchanging laws. Instead, these recent, complex frameworks are designated as theories to acknowledge that they are conditional and may be part of a larger, more complete future framework.

View the evolution of atomic models, with four successively overturned between 1900 and 1926

Originally thought to be indivisible spheres unique to each element, the discovery of the electron by J.J. Thomson revealed them to be made of smaller particles. Ernest Rutherford's gold foil experiment uncovered the existence of nuclei, which Niels Bohr suggested were surrounded by electrons in fixed orbits. By applying quantum mechanics, Erwin Schrödinger replaced orbits with probability clouds.

Distinguishing between scientific theories and laws, and why both are on equal footing

Scientific laws describe outcomes of specific conditions, and scientific theories explain why those outcomes occur. Both are supported by observational and experimental data and can each inform one another, but neither can become the other. Instead, additional data can improve each towards more accurate descriptions and explanations of reality.

The quantum model of the atom resulted from over two millennia of scientific thinking

In 440 BCE, Democritus proposed that everything was made up of tiny particles surrounded by empty space, which varied in size and shape based on the substance's properties. It was not until the 20th century that experimental evidence validated elements of Democritus' model.

The history of chemistry up to World War I, from alchemists seeking gold to probing atomic structure

Those involved in the predecessor of the modern scientific discipline engaged in experimentation to develop recipes that would transform ordinary matter into gold and to create medicines, cosmetics, dyes, and alloys. Over the course of centuries, scientists identified unique elements, organized them based on their properties in the periodic table, and eventually developed the technology to discover the internal structure of atoms.

How facts, hypotheses, theories, and laws in science differ from everyday language

Facts are observations of the world, and they can be pooled together for a given phenomenon to develop a hypothesis—a proposed explanation consistent with observations that requires further investigation. Experiments and additional data can rule out many hypotheses or graduate a proposed explanation into a widely accepted and validated theory.

One doctor argued vampires were based on a real disease

At a conference in 1985, Canadian biochemist David H. Dolphin posited that stories of vampires and werewolves had a real-world origin. He argued that porphyria could have caused sufferers to seek out blood, as well as experience light sensitivity and an aversion to garlic. More than one article in the 1990s discredited this take.

The simple grandeur of atomic theory

Is the universe made up of a continuous substance, or a finite amount of tiny, indivisible atoms? The atomic hypothesis, largely vindicated in the 20th century, was forgotten for nearly 2,000 years after first being formulated by the Greek philosopher Democritus. Learn more about the theory and its implications for science and human life with this reflective essay.

An overview on germ theory, the crucial framework developed by Louis Pasteur

Germ theory of disease is based on the concept that many diseases are caused by infections with microorganisms, typically only visualized under high magnification. Read this general overview to understand the basic framework which allowed for development of vaccines.

A brief history of human blood groups

The blood group that determines whether you have type A, B, AB, or O blood was discovered near the turn of the 20th century. This short academic article dives into three main theories about the evolution and emergence of blood groups, the exact nature of which remains unclear.

The one-electron theory describes the universe as having only one electron

The thought experiment explains why every electron has the same charge and mass as every other electron, and describes every positron—the antimatter version of the electron—as that same electron traveling backwards in time. Among other foundational challenges, the model suggests that the universe contains equal numbers of electrons and positrons, yet normal matter is much more common than antimatter.

10 Shakespeare authorship theories

Although William Shakespeare is widely considered to be the authentic author of the plays attributed to him, there are still dozens of theories suggesting that others are responsible for the classic works. Was it actually his contemporary, Christopher Marlowe? Or maybe his wife, Anne Hathaway? This list explains the 10 most popular theories that have been proposed, much to more than a few Shakespeare scholars' chagrin.

Scientific progress works toward absolute truth, but can never reach it

Through the acquisition of scientific knowledge, scientists construct explanations of the world, which are rigorously tested and verified until they narrow down to a leading theory of the natural world. However, because of how science works, these ideas will never become factual, as they must always remain open to be iteratively revision based on new data.

Browse and explore dozens of major psychology theories

There are a ton of different psych theories—so here's a breakdown of some of the major ones according to the general psychological focus.

Benjamin Franklin once wrote a satirical essay about passing gas

The Founding Father was asked to judge a contest for the Royal Academy of Brussels, but was incensed by one of the contest's questions, which he believed was highly impractical. In response, he wrote a piece suggesting that the most essential problem for scientists to solve was the "fetid Smell" that came with passing gas.

Hippocratic doctors treated severe mental illness with the poisonous plant hellebore

Since symptoms like hallucinations were believed be due to an imbalance of black bile, yellow bile, blood, and phlegm, the treatment at the time was to bring those humors back into balance. That meant standard treatments could include bleeding a patient or using substances like hellebore to induce vomiting or diarrhea.

How upheavals in accepted scientific theories helped popularize the term 'paradigm'

When Thomas Kuhn published "The Structure of Scientific Revolutions" in 1962, he described the history of science as comprising periods of "normal science" where these accepted frameworks—paradigms—gradually accumulate anomalies until they cannot describe nature. Revolutionary science, such as the development of a new theory, results in a paradigm shift, another term Kuhn helped popularize. (Some readers may experience a paywall.)

The theory of plate tectonics was not initially accepted until evidence became undeniable

Alfred Wegener proposed continental drift—the movement of large landmasses—in 1912 to explain why similar rock layers, plant and animal fossils, and glacial deposits were found on continents that were then unconnected. In the early 1960s, this was combined with evidence of seafloor spreading, mantle convection in Earth's interior, and earthquake and volcanic data outlining plate boundaries to produce the accepted theory.

The theory of chemtrails originated from misinterpreting a US Air Force paper

The document proposed a future weather modification system to achieve military objectives, but clarified that such a system "does not reflect current military policy, practice, or capability." Past testing of biological and chemical weapons has accelerated conspiracies about streaks of condensation trailing aircraft to be harmful chemical agents.

Validation of the greenhouse effect may have been misattributed

Although Irish physicist John Tyndall showed in 1859 that water vapor and carbon dioxide could absorb and radiate infrared radiation, experiments by American scientist Eunice Foote three years earlier identified the same phenomenon for light in general. Historically overshadowed, her work was rediscovered by female historians over a century later.

The Big Bang theory explains the expanding universe and its fiery early origins

The term “Big Bang” was initially coined by a skeptic of the theory, but the name stuck despite the theory not depicting a "bang." The event took place everywhere in the universe at once, and the theory explains the abundance of hydrogen and helium in the universe.

A timeline of the science of taste discoveries

The tongue is made up of four types of papillae—elevated, nipple-like projections that give the organ its rough texture. In the early 1900s, initial research into the tongue's varying taste sensitivity led to a misleading map of the tongue and its taste regions. Over the decades, researchers fleshed out five distinct tastes (and more recently, a sixth).

Why some people have allergies

Why do some people have allergies while others don’t? One theory suggests allergies are a relic of our evolutionary past. Our immune system, once primed to fight parasites, now mistakes harmless substances for threats.

Once called 'aces,' quarks are fundamental pieces of matter that combine to create over 100 known composite particles, including the proton and neutron.

Create anything from the elements in Little Alchemy 2

Various ancient cultures believed the most abundant substances in the world were its basic elements: earth, water, air, and fire. We may know better now, but you can make almost anything from those four things. Little Alchemy 2 is a fun, cartoonish game that allows users to create more complex items from simple substances.

Modern physics suggests that many universes with different physical laws could exist

Physicists suggest that quantum fluctuations in the early universe could have given rise to these universes. Ancient Greek philosophers like Chrysippus proposed a version of the multiverse over 2,000 years ago—millennia before its adoption into various theoretical frameworks today.

Six of history's most unethical human experiments, from deliberate flu exposure to withholding syphilis treatment

Some of the progress made in mental health treatment, vaccines, blood transfusions, and more came about before the advent of consent and ethics committees, resulting in serious physical and psychological harm that participants in studies were not even anticipating.

Everything you know about Phineas Gage is wrong

A stray spark sent a 3.5-foot-long, 1.25-inch thick iron rod through the brain of foreman Phineas Gage in 1848, creating a scientific case that has attracted onlookers for nearly two centuries. His life reportedly soon spiraled out of control, with his behavior tending toward selfishness and chaos. Evidence of these changes is far less common, with Gage's story bloated by fabrication, scientific prejudice, and artistic license.

Explore an interactive map of the unified theories of everything

This interactive concisely describes many highly complex theories ranging from quantum gravity and black holes to dark matter and energy. Supplementary resources, key questions, and possible solutions accompany each description. As of 2026, no developed theory provides an accepted explanation of all observed phenomena in the universe at all scales.

More than 90% of the atoms in the human body were forged by stars, with almost three-quarters originating from the explosion of massive stars.

Antimatter was predicted to exist four years before it was observed, though the mathematics responsible for the prediction described it as matter with negative energy.

Smaller than atoms—what are quarks?

One of humanity’s eternal questions surrounds what we are fundamentally made of. Many ancient philosophies believed in a set of classical elements: from water, air, fire and earth of ancient Greeks; to…

The history of the periodic table and how it hinted at atoms possessing internal structure

In 1869, more than two decades before the discovery of electrons, Russian chemist Dmitrii Mendeleev organized known elements by atomic weight and chemical properties using index cards. His organization revealed previously undiscovered elements and identified patterns in the reactivity of elements, which would later be linked to each element's outermost electron shell. (Some readers may experience a paywall.)

History's weirdest weight loss fads, fact-checked

Nothing catches popular attention more than a claim to have found a quick weight-loss technique. History shows us such claims are often unfounded. Dr. Michael Mosley explores extreme weight-loss tips from history, from tapeworms to vinegar diets.

The history of molecular gastronomy, from thickening yolks with alcohol to making art with food

Before understanding why they worked, humans used scientific principles, including designing solutions and analyzing outcomes, to develop preservation methods like curing meat and fermenting vegetables. By the 20th century, the application of industrialized food preparation to smaller kitchens set the stage for the subdiscipline of food science.

Solar eclipses block the sun enough to enable scientists to observe its faint outer atmosphere, or corona, whose spectrum led to the discovery of helium over a decade before it was identified on Earth.

Using scientific bets, Hawking challenged and highlighted major physics ideas

Hawking famously placed wagers on high-stakes questions in theoretical physics—such as the Higgs boson—for fun and to draw attention to science. When Hawking lost a bet about Cygnus X-1 being a black hole, he paid up with a magazine subscription.

Five potential ways to achieve time travel

While the author discounts the possibility of traveling to the past, it lays out five hypothetical modes of catapulting into the future: speed, gravity, suspended animation, wormholes, and light. Each has some scientific basis, but none are realistic for humans. Read the article to learn where they offer promise and where they fall short.

As of 2025, the Standard Model has at least five unresolved problems

Among the issues with the most successful theory of the universe at subatomic scales is its inability to explain the extreme imbalance observed between visible matter and antimatter, since both should be roughly equal. The Standard Model also omits gravity and cannot account for the observed rate of cosmic expansion.

Discover the chemistry behind smoking foods, including the types of smoking and the source of smoking flavors and colors.

Quantum mechanical principles are responsible for chemical properties

Besides quantization, the wave-particle duality, and probabilistic features, quantum theory's mathematics introduces the exclusion principle, quantum tunneling, quantum entanglement, and other phenomena foreign to our everyday experiences. Some suggest that all possibilities for a quantum system may also occur across the multiverse.

Explore a simulation of ideal gas behavior, which can be explained by kinetic molecular theory

The theory describes particles as moving in random directions, with a distribution of velocities determined by the gas's temperature. The particles collide elastically like billiard balls, are negligibly small, and do not exert forces on one another. The gas laws can be derived from these principles using statistics or observed via this interactive.

The invention of the barometer proved that air has weight

The instrument measures air pressure by creating a partial vacuum—a region with very low density—which serves as the basis for how suction works. Mercury-based barometers were used until 2007, when they were restricted due to mercury's toxicity.

Light has been modeled as a wave and a stream of particles throughout history

Isaac Newton first identified white light as composed of a spectrum of colors, which he believed consisted of particles of different hues. Various light phenomena, including refraction, led Christiaan Huygens to develop an alternative wave model. Quantum mechanics validated both models through the concept of wave-particle duality.

Blood has evolved many times over hundreds of millions of years, resulting in different blood colors and compositions—and there are even some organisms that don't need blood at all.

JJ Schildkraut theorized depression is linked to brain chemical imbalances—in 1965

Schildkraut was one of the first to put forward this idea, which stemmed from lab animal research. A decade later, researchers published the first landmark paper on fluoxetine—better known by trade name Prozac—which increases serotonin levels in the brain.

Before discovering cells, life was believed to emerge suddenly from inorganic matter

Popularized by Aristotle in the 4th century BCE, spontaneous generation was used to explain phenomena like mice appearing in seemingly sealed grain storage. The invention of the compound microscope in the late 16th century led to the identification of cells as the basic unit of life, but it was not until 1855 that their origin from preexisting cells was established.