The history of chemistry up to World War I, from alchemists seeking gold to probing atomic structure

The history of the periodic table and how it hinted at atoms possessing internal structure

In 1869, more than two decades before the discovery of electrons, Russian chemist Dmitrii Mendeleev organized known elements by atomic weight and chemical properties using index cards. His organization revealed previously undiscovered elements and identified patterns in the reactivity of elements, which would later be linked to each element's outermost electron shell. (Some readers may experience a paywall.)

The history of molecular gastronomy, from thickening yolks with alcohol to making art with food

Before understanding why they worked, humans used scientific principles, including designing solutions and analyzing outcomes, to develop preservation methods like curing meat and fermenting vegetables. By the 20th century, the application of industrialized food preparation to smaller kitchens set the stage for the subdiscipline of food science.

Create anything from the elements in Little Alchemy 2

Various ancient cultures believed the most abundant substances in the world were its basic elements: earth, water, air, and fire. We may know better now, but you can make almost anything from those four things. Little Alchemy 2 is a fun, cartoonish game that allows users to create more complex items from simple substances.

By organizing elements by atomic weight, Dmitri Mendeleev created the periodic table

The organization included groupings based on similar chemical properties and patterns in atomic weights. This left gaps that were used to predict the properties of elements yet to be discovered—including germanium and gallium—with high accuracy.

Explore an interactive periodic table of each element's history, properties, and uses.

The history of metallurgy: an interactive timeline

Humans have long been shaping metals into useful tools and aesthetic accessories. By 8,700 BCE, humans already had mastered four types of casting copper. Within a few thousand years, people were combining metals to make the alloy bronze and had...

The quantum model of the atom resulted from over two millennia of scientific thinking

In 440 BCE, Democritus proposed that everything was made up of tiny particles surrounded by empty space, which varied in size and shape based on the substance's properties. It was not until the 20th century that experimental evidence validated elements of Democritus' model.

At the Large Hadron Collider, scientists have transformed lead into gold—a process known as chrysopoeia, which alchemists sought for centuries.

The simple grandeur of atomic theory

Is the universe made up of a continuous substance, or a finite amount of tiny, indivisible atoms? The atomic hypothesis, largely vindicated in the 20th century, was forgotten for nearly 2,000 years after first being formulated by the Greek philosopher Democritus. Learn more about the theory and its implications for science and human life with this reflective essay.

View the evolution of atomic models, with four successively overturned between 1900 and 1926

Originally thought to be indivisible spheres unique to each element, the discovery of the electron by J.J. Thomson revealed them to be made of smaller particles. Ernest Rutherford's gold foil experiment uncovered the existence of nuclei, which Niels Bohr suggested were surrounded by electrons in fixed orbits. By applying quantum mechanics, Erwin Schrödinger replaced orbits with probability clouds.

Learn the history of food science breakthroughs from the 20th century

Long after humans developed the means to produce sufficient food to feed civilizations, scientific research focused on a wide variety of objectives, such as developing methods to preserve food quality (accomplished via frozen food), speeding up cooking (leading to the microwave), and lowering the cost of sweetening food, which high fructose corn syrup provides.

Exploring World War I technology on the battlefield

Industrialization brought massive changes to warfare during the Great War. Newly-invented killing machines begat novel defense mechanisms, which, in turn spurred the development of even deadlier technologies. Nearly every aspect of what we would consider modern warfare debuted on World War I battlefields. Starting with soldiers on horseback carrying lances and ending in poison gas, machine guns, and aerial battles, this gallery shows the first tools of modern warfare.

The pharmaceutical industry evolved, in part, from the discovery of synthetic dyes

In 1856, a chemist accidentally discovered mauveine, the world's first synthetic dye, while trying to make quinine to treat malaria. The synthetic dyes that followed helped reveal germs under microscopes, paving the way for modern imaging techniques and breakthrough treatments, such as antibiotics.

Learn more about the history of fireworks, which date back to an accidental invention during an alchemist's quest for information about immortality.

The periodic table organizes elements by atomic structure and common properties

Developed by Dmitri Mendeleev in 1869, the arrangement places elements into columns, called groups, if they share the same number of electrons in their outer shell, indicating similar chemical behavior. From left to right across rows, or periods, elements have more protons, as well as corresponding electrons when neutral.

Building the first atomic bomb required unprecedented coordination

Creating the first atomic bombs demanded breakthroughs in physics, engineering, and logistics—uniting elite scientists with tens of thousands of workers across the US. This in-depth history explains how the Manhattan Project overcame those challenges.

Before 1932, when particle accelerators were first used for nuclear research, scientists relied on naturally radioactive substances to advance their understanding of the atomic nucleus.

Explore the chemical compounds found in fireworks

Besides the various salts and metals used to produce fireworks colors, shells are also filled with gunpowder and oxidizers to help fuel and accelerate reactions. Chlorates help strengthen colors, while dextrin, a starch, helps hold mixtures together.

Gold's electrical conductivity, reflectivity, and catalytic capabilities make it scientifically valuable

Although gold has been prized since its use in 40,000 BCE for decorative purposes, it has more recently served as a replacement for mercury in the production of PVC plastic. Because gold does not react with air or corrode, it has remained in circulation and reused in electronics and biomaterials.

When did people start making and using glass?

This article details the search for the ancient origins of glass, a now-common item through which archaeologists can spot histories of trade and innovation. Bronze Age glass was made from crushed quartz instead of sand, and artisans could color glass with materials such as cobalt. These trace metallic add-ons have given scientists a vital clue into the origins of glass, which is currently debated as either Egypt or the Near East.

The origin of atmospheric science while testing nuclear weapons during the Cold War

The arms race between the US and the Soviet Union saw both countries stockpiling and detonating hundreds of bombs underground, underwater, and in the atmosphere. To better predict where nuclear fallout would travel after these tests, scientists developed models that would serve as a foundation for those used to explain atmospheric circulation.

The outermost shell of electrons in an atom dictates how it bonds to other atoms, including those of the same element, and the properties of the materials composed of those atoms.

The history of soap and how it forms bathtub scum and white spots in old oil paintings

Soap has been produced since at least 2,200 BCE via a chemical reaction between fats or oils and a base. This creates salts that act as molecular bridges, helping water lift dirt and grease from surfaces. The same chemistry produces scum when metals in hard water bind to soap molecules, as well as white spots in paintings when metal ions in pigments react with fatty acids in the oil binder.

Ernest Rutherford's gold foil and nitrogen experiments revealed nuclear structure

Observing high-angle deflections when alpha particles were fired at gold foil led to an atomic model with a dense, positively charged nucleus. Firing those particles at nitrogen resulted in the emission of hydrogen nuclei—protons—leading to the discovery of the subatomic particle.

Besides the periodic table, there are over 1,000 alternative ways to organize the known elements, with many arrangements emphasizing specific trends among them.

More than 90% of the atoms in the human body were forged by stars, with almost three-quarters originating from the explosion of massive stars.

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

The Curies developed a way to measure radioactivity in an old medical dissecting room

Despite lacking proper laboratory conditions, Marie and Pierre built an ionization chamber and a piezoelectric quartz electrometer to measure the amount of charged particles released by radiation, with a sensitivity of ten-trillionth of an ampere. Substances with different emission rates indicated different elements.

Listen to how the 1902 'poison squad' experiments changed food safety in America

As part of government research, a group of young men were paid to eat standard American food—replete with food additives like borax and formaldehyde—which revealed the dangers of unregulated food. The work was led by the first FDA commissioner, Harvey Wiley, who helped end the "century of the great stomachache."

How a government chemist founded the FDA—by poisoning people

The Poison Squad tells the story of government chemist Dr. Harvey Wiley who, determined to banish these dangerous substances from dinner tables, took on the powerful food manufacturers and their allies.

Visualizing the chemistry of nuclear weapons

Nuclear weapons have devastating effects, but the science of how they work is atomically small. There are two main types of nuclear reaction: fission and fusion. The fission bomb produces immense energy by splitting an atom, the result of firing a...

Meet the scientists who worked on the Manhattan Project.

The origin of the term 'molecular gastronomy' and its first international workshop

The 1992 event was born from a conversation between American cooking instructor Elizabeth Cawdry Thomas and Italian physicist Ugo Valdrè, who agreed on the merits of the science of cooking. The International Workshop on Molecular and Physical Gastronomy was named, in part, after the field of molecular biology to lend it prestige and greater seriousness.

A list of five scientific theories that were accepted and later disproved

Humoral theory held that everyone's personality derived from different combinations of four bodily fluids: blood, phlegm, yellow bile, and black bile. The phlogiston theory stated that all combustible materials possessed a fire element—phlogiston—that was released and absorbed by the air during burning. When the air became saturated with phlogiston, the fire would go out.

The origin of the National Science Foundation and why World War II led to its founding

Before World War II, research institutions were funded by endowments or private companies whose priorities stifled the curiosity-driven science that fueled significant breakthroughs and innovation. The NSF was established in 1950 to promote independent scientific progress through basic research, which is focused on knowledge acquisition rather than commercial applications, conducted at national colleges and universities.

The history of blood, as told by a hematologist

Since ancient times, blood has been seen as a semi-magical substance. Alchemists theorized it was a mixture of the four elements. Others proposed it was one of four bodily fluids whose balance dictated health. This 2019 essay by a hematologist reviews blood's reputation across cultures and centuries.

How scientists determine elemental composition based on the light emitted by cooling atoms

When electrons within an atom drop to a lower energy level closer to the nucleus, they lose energy and produce light with energy equal to the difference between the two energy levels. Because these levels and the corresponding emitted light are unique to each element, the light serves as a unique signature that can be compared to known lab samples for identification.

English chemist Rosalind Franklin (1920 - 1958) on the importance of science

"Science and everyday life cannot and should not be separated. Science, for me, gives a partial explanation of life."

Build atoms to learn about atomic number, mass number, and charge notations

In this simulation, users can add protons, neutrons, and electrons to create atoms, view their stability and atomic configurations, and identify how the amounts of these subatomic particles are detailed around the abbreviation for the resulting element using AZE notation.

Fusion reactions and radioactive decay produce elements inside stars

Hydrogen, present since the early universe, serves as fuel for the proton-proton chain, producing helium, which is then incorporated into the CNO cycle to produce carbon, nitrogen, and oxygen. Additional fusions of helium with these elements and subsequent decays via the alpha ladder produce elements up to iron and bismuth.

Before discovering cells, life was believed to emerge suddenly from inorganic matter

Popularized by Aristotle in the 4th century BCE, spontaneous generation was used to explain phenomena like mice appearing in seemingly sealed grain storage. The invention of the compound microscope in the late 16th century led to the identification of cells as the basic unit of life, but it was not until 1855 that their origin from preexisting cells was established.

View the most expensive materials on Earth, led by antimatter and other elements forged in particle accelerators.

In 1880, Jacques and Pierre Curie discovered that electricity could be produced by striking certain materials—the piezoelectric effect—a phenomenon that is seen in barbecue lighters.

Why it's so hard to end the use of toxic lead

Lead was one of the earliest metals mined on Earth, desired for its soft malleability and used in cosmetics, pipework, gasoline, and more. But even though researchers demonstrated its toxicity in the 20th century, much of the world still uses it.

Two-thirds of antibiotic classes were made between the 1940s and 1960s

The vast majority of bacterial treatments were developed during the "Golden Age of Antibiotics," an era of rapid innovation and drug discovery that led to the reduction of millions of deaths worldwide. Since 1970, only eight new antibiotic classes have been discovered.

The cosmic dark ages: before stars existed

The theories behind the Big Bang suggest the process of the universe beginning to the creation of stable, neutral atoms took just half a million years. But the transition from such atoms to star formation took surprisingly much longer, upwards of 100 million years. Why? This deep dive explores the science behind the unique physical composition of the so-called cosmic dark ages.

Exploring carbon compound pore structures contributed to improved gas mask filtration

During World War II, the British Coal Utilisation Research Association sought to improve the efficiency of coal as an energy source and studied the effectiveness of charcoal filters to keep soldiers safe. Rosalind Franklin's research there formed the basis of her PhD and led to five scientific papers.

See how antidepressants—used by roughly 1 in 10 Americans—were discovered.

X-rays earned the very first Nobel Prize in physics for revealing hidden worlds

In 1895, Wilhelm Conrad Röntgen discovered X-rays, which could pass through solid objects and make unseen structures visible. Today’s X-ray tools continue to advance science and medicine, including capturing real-time images of proteins.

Smaller than atoms—what are quarks?

One of humanity’s eternal questions surrounds what we are fundamentally made of. Many ancient philosophies believed in a set of classical elements: from water, air, fire and earth of ancient Greeks; to…