What is Captagon, the addictive drug mass-produced in Syria?

Mapping where the drug captagon is seized worldwide

In the 1960s, Captagon was patented in Germany as a stimulant similar to amphetamines. It was prescribed for a time to address narcolepsy, ADHD, and other conditions. As its addictiveness and psychosis-inducing quality became more apparent, the drug has been banned in many countries. A robust illicit manufacturing of the drug endures in the Middle East, especially in Syria and Lebanon. Track locations where the drug has been seized on this updated map.

Drug trafficking in the MENA

The Middle East and North Africa is a major source, transit point, and consumer of illicit drugs. Despite having some of the harshest penalties for drug-related crimes, the region both influences and is negatively impacted by illicit substance abuse...

How the Myanmar coup fueled a rise in illegal drugs

According to the UN, Myanmar remains the world’s second-largest producer of heroin. Inside Myanmar, almost all the drugs come from one place: Shan state in the Golden Triangle region, south of China, where Myanmar meets Thailand and Laos. The...

The International Olympic Committee banned ibogaine decades ago

Beyond use by athletes as a stimulant before the ban, the drug has a long history. The psychoactive substance was also mass produced in the mid-20th century by a French pharmaceutical company as a product called Lambarène, which was marketed as a cure for conditions including depression and lethargy. Production halted in 1966, however, when ibogaine-containing products became illegal in France.

Why Belgium is now the cocaine capital of Europe

Belgium has become Europe's cocaine-trafficking capital. Recently, Belgian ports have seen record seizures of cocaine. In 2020, the port of Antwerp accounted for 40% of all cocaine seizures in the EU. And local authorities are struggling with the...

Step inside Colombia’s most powerful drug trafficking group

The AGC is Colombia’s most powerful drug trafficking organization. Founded by a paramilitary leader who dismissed the Colombian peace process, the AGC stands for the Gaitanist Self-Defense Forces of Colombia. Self-described as “an army fighting...

Ramadan is a major television event in the Middle East

Each year, major networks air special 30-episode dramas timed to the month—one episode per night after iftar. Syrian productions long dominated the format, though that has shifted. The season is the advertising event of the year across the Middle East, rivaling the Super Bowl in commercial intensity.

How the Montreal Protocol made CFCs the most valuable Miami contraband after cocaine

Following the 1990s production ban, smugglers flooded Miami with illegal chlorofluorocarbons used in air conditioning. A 15-kilogram cylinder bought for $70 in Europe could sell for $242 in the US, fueling multimillion-dollar black-market trade. (Some users may experience a paywall.)

Watch the craziest ways cartels traffic drugs

The war on drugs has forced cartels to be increasingly creative when it comes to smuggling drugs. As police develop methods to catch smugglers, drug traffickers come up with new ways to get their products from producer to seller to buyer. This cycle...

How drug trafficking undermines West Africa

The rise of drug trafficking is undermining institutions, public health, and development efforts in West Africa. According to the West African Commission on Drugs, civil wars have receded, democracy has gained ground, and economies are growing in...

Why are drug dealers putting fentanyl in everything?

A few grains of fentanyl, a synthetic opioid far more potent than heroin or morphine, are enough to kill a typical adult human. It's made its way into other, less lethal street drugs, where it may be used to increase the highs experienced by unknowing users, increasing their likelihood of addiction and overdose.

Drug trafficking, violence, and politics in Northern Mali

Drug trafficking in northern Mali is fueling unparalleled regional violence and instability. In Mali, smuggling narcotics is not only a way armed groups gain funds, but also a source of conflict in itself. According to the International Crisis Group...

Merck developed MDMA in the early 1900s as part of its effort to create a blood clotting drug

The company's chemists were attempting to synthesize a substance that could compete with an existing patent for the best clot medicine of that time, hydrastinine. MDMA was the byproduct of that effort.

CIA factbook on the Middle East

The CIA’s World Factbook provides a comprehensive overview of 19 Middle Eastern nations. A wide range of background information is provided for: Armenia, Azerbaijan, Bahrain, the Gaza Strip, Georgia, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon,...

Compounding pharmacies make custom drug formulations during drug shortages

Compounded semaglutide refers to customized versions of the medication prepared by pharmacies, especially during shortages of FDA-approved products like Ozempic and Wegovy. While compounded forms of brand-name medications can make it easier to access the drugs, the quality of such medications often varies.

Some invasive species' populations have been controlled by turning them into cash crops that can be harvested and sold to produce useful materials.

Synthetic pheromones may protect coral reefs by attracting their predators

Researchers in Australia and Japan have developed these nontoxic chemicals to attract crown-of-thorns starfish, which consume corals that make up the Great Barrier Reef. As of 2026, synthetic pheromones have been shown to be effective in lab trials, and future field trials will attempt to lure starfish into areas for mass removal.

Morphine, heroin, codeine, and more were derived from opium

Opium reached the US at about the time early colonists were itching for ways to soothe aches and pains. The active ingredient in the substance was isolated in the early 19th century, eventually leading to the manufacture and commercial sale of morphine, heroin, and other opium-based drugs.

Synthetic opioids: a historical and clinical review

In the 19th century, researchers began synthesizing and isolating poppy plant alkaloids, leading to the invention of morphine, codeine, heroin, oxycodone, and others. These highly addictive variants eventually gave rise to illicit use and a widespread underground market, laying the foundation for the current opioid crisis.

As oil revenues decline, many Gulf States are investing in professional sports through sovereign wealth funds

Gulf States—including the United Arab Emirates, Qatar, and Saudi Arabia—have invested tens of billions of dollars in professional sports, owning high-profile soccer clubs like Paris Saint-Germain and Manchester City. Many of these investments have been characterized as an increase in these countries' soft power, or global cultural influence, in Western countries, where the Middle East remains relatively misunderstood.

A podcast detailing the drug markets of East and Southern Africa

The African continent plays a critical role in the global illicit drug market. Often forgotten when discussing drug trafficking, organized criminal networks in Africa have established relationships with other criminal organizations around the world....

An eye-opening interactive journey into the global drug trade

POPPY Interactive reveals how drug money destabilizes entire countries, fuels global conflicts, and allows a worldwide illegal economy to grow. Navigating the site involves diving into three major routes—the Northern Route, the Balkan Route, and...

Cocainenomics

How did Pablo Escobar rise up out of the Medellin barrios to become the CEO of a $4 billion business? This immersive look at the global drug trade spawned by the notorious drug lord, who at his peak controlled 80% of the cocaine supply in the US. This deep dive includes visualizations showing how logistics of drug smuggling evolved over the years and traces the economic impact of the industry.

Read the FDA's statement on concerns over compound pharmacies

GLP-1 drugs popularity for weight loss and treating diabetes, led to a significant supply shortage and the rise of compound pharmacies, which produce customized drug formulations but lack formal approval from regulators. The drugs are ostensibly the same, but manufacturing methods lead to variations in concentration, filler compounds, and more.

A map of global drug trafficking

The worldwide illegal drug trade continues to flourish. Accounting for almost 1% of the world’s financial revenue, the cocaine trade alone boasts an annual turnover of an estimated $85 billion. This infographic, from Around the World: An Atlas for...

Michael Sveda discovered cyclamate by accident

When this lab researcher brought his hands to his lips to smoke his cigarette in 1937, he tasted something sweet, which he called cyclamate. It was quickly used in diet sodas, but it was banned from the US in 1969 after being linked to rodent bladder cancer in lab experiments.

Is there an arms race in the Middle East?

In 2021, countries in the Middle East spent $168 billion on weapons. Defense spending in the Middle East has been falling in the last few years, but this doesn’t necessarily mean that the region is de-militarizing. In 2021, Saudi Arabia spent $55...

Addictive drugs can cause dopamine levels to become ten times higher than normal.

Ibogaine, a psychedelic substance, can be used to treat mental illness

Although the substance is banned in the US, it's legal in Mexico. Americans who have traveled there for treatment, including the NFL's Braden Smith, say the drug helps deal with conditions like obsessive-compulsive disorder.

Ibogaine is being investigated for treating mental health issues and substance abuse

This compound, which is illegal to use in the US, has had promising results for patients who have tried it in other countries for substance abuse and mental health concerns. This psychoactive substance is not without risks, however; this TED talk points out it's also caused fatal cardiac arrhythmias and shouldn't be taken without medical supervision.

How five of the world's most expensive salt and spices are made

Part of the charm of certain spices and salts is their exotic origin, hailing from difficult-to-access locales or hewn via special processes. That also explains why they can be so expensive. Dive into the businesses of producing and marketing five of the world's most expensive food additives with this engaging video.

Syrians in their own words

The conflict in Syria is still alive after 10 years. Thousands of Syrians have been reported missing, hundreds of thousands reported dead, and millions have been displaced. The ICRC (International Committee of the Red Cross) asked 1,400 Syrians...

Fast, cheap, and deadly: How fentanyl replaced heroin and hooked America

This interactive article details how fentanyl has largely replaced heroin in the drug trade, with fatal results. Fentanyl was first developed in 1959 as an anesthetic for pain relief, but the drug took hold in the US black market in 2014 and has since exploded in the intervening decade.

Sovereign wealth funds in the Middle East and Asia surged after the 2008 financial crisis.

Visualize the global supply chain of medicine, which may begin with basic research in the US, but outsource intermediate steps.

Why is fentanyl poisoning street drugs?

A few grains of fentanyl, a synthetic opioid far more potent than heroin or morphine, is enough to kill a typical adult human. It's made its way into other, less lethal street drugs, where it may be used to increase the highs experienced by unknowing users, increasing their likelihood of addiction and overdose. This 39-minute podcast episode is the first half of a two-part series exploring fentanyl's rise.

Evidence of opium use dates to as early as 5000 BCE

Archaeological evidence shows the use of the poppy plant for its pain-killing properties likely originated in the Mediterranean before making its way to the East and West via trade. It has since inspired two eponymous wars, and highly addictive derivatives of the naturally occurring substance have led to an ongoing overdose crisis.

Gulf nations produce about 40% of the world's desalinated water

According to a 2023 report, six Gulf states produced 1.9 trillion gallons of freshwater across more than 400 desalination plants along their coasts. These plants create water suitable for human consumption by boiling saltwater and collecting steam or using high-pressure pumps to push seawater through a filter that only allows water molecules through.

A video showing how drug dealing really works

What motivates people to sell drugs? The "News on Drugs" series asks how people get drawn into the drug trade, unpacking the different goals and aims involved in dealing drugs. While there is a lot of focus on cartels, traffickers, and gangs...

Rome's herbal panacea may not be as extinct as we thought

Silphion: cure-all, aphrodisiac, birth control, tasty seasoning. Nero allegedly ate the last of this miracle plant. This article details how a researcher may have found more. Seven centuries after the yellow-flowered plant was first documented growing in what's now Libya, it vanished. Historians proposed that the loss of Silphion may have been the first recorded extinction of any species.

An interactive investigation into drugs and migration in San Francisco

This interactive article investigates the connection between the boom in US migration from Honduras and drug dealing in San Francisco. A high concentration of Hondurans are fleeing Siria Valley, where poverty and national murder rates run high...

Spare capacity is the amount of oil production that can be brought online within 30 days and sustained for at least 90 days

Specifically, a country’s “spare capacity” signifies the difference between its maximum sustainable oil production and its current output. OPEC member countries hold nearly all of the world’s spare oil production capacity. Historically speaking, Saudi Arabia has been the country with the largest spare capacity.

Saudi Arabia began investing in international sports in the mid-2010s

The country's Crown Prince Mohammed bin Salman has argued that embracing sports and tourism will diversify the Saudi economy away from a dependency on oil. Critics argue the events are being used to distract from the regime's human rights violations.

Fentanyl can be up to 100 times more potent than morphine

A synthetic opioid, fentanyl is highly addictive and incredibly fast-acting—a fatal dose is equal to a few grains of table salt. Once it enters the body, fentanyl floods naturally occurring opioid receptors, which can cause the body to shut down its breathing reflex, leading to a fatal overdose.

The story of the Sackler empire behind highly addictive OxyContin

This investigative report examines how the Sackler family built its fortune through Purdue Pharma’s aggressive marketing of OxyContin, a highly addictive painkiller. Through 2017, the drug had generated more than $30B in sales for Purdue Pharma, controlled by the Sacklers.

Salt is harvested from briny ocean water and underground deposits

Mostly sodium chloride, this compound is produced for human use by collecting seawater in shallow pans and allowing the Sun to evaporate the water until crystals remain. Underground rock salt is mined, crushed, and purified from deposits left behind by ancient seas that have dried-up.

How to make LSD

Lysergic acid diethylamide, often shortened to LSD, comes from ergot, a parasitic fungus that can be found in grains. Chemists rearrange the fungus' chemical structure or the structure of an ergot derivative through complex chemical reactions, transforming it into the hallucinogenic bicycle-shaped LSD crystal. Due to the partially synthetic drug's criminalization, many of the details of modern LSD crafting honed by "underground chemists" are kept secret.

The Sykes-Picot agreement as seen through Arab eyes

After WWI, the borders of the Middle East were redrawn by two men: Mark Sykes (UK) and Francois Picot (France). Signed in 1916, their secret agreement divided one of the most volatile regions in the world into states, cutting through ethnic and...

A 101 on the 'Death Cap,' the world's deadliest mushroom

The Death Cap, also known as amanita phalloides, is the most fatal mushroom on the planet, responsible for roughly 90% of the world's mushroom deaths per year. Ingestion of the mushroom wreaks havoc on the liver and kidneys, frequently leading to...

The US war on drugs, explained

The United States has been fighting a global war on drugs for decades. By making drugs more expensive and less available, the US has sought to reduce drug use and inhibit the international drug trade. However, increasing prison populations,...