The canal carried germs as well as goods

Cholera went global thanks to global trade

The first cholera pandemic grew from an outbreak in India, in 1817. Scientists suggest it spread from there throughout the continent and onward to Africa, Russia and Europe through the poop of traders.

The Erie Canal fueled a surge in westward settlement

By providing cheap, reliable transport to the interior, the canal made western lands more accessible. Farmers, traders, and immigrants moved into the Great Lakes region, accelerating population growth.

Travel the 363-mile Erie Canal, the waterway that cut freight costs by 90% and opened the American frontier.

The canal became a highway for American reform movements

Beyond goods, the canal carried ideas. Its corridor hosted Second Great Awakening revivals and became a center for activism—fueling abolitionist networks, women’s suffrage organizing, and other reform movements.

The Erie Canal was opened Oct. 25, 1825, with a group of boats from Buffalo to NYC

The unlikely engineering project connecting the Midwest to the Atlantic saw a ceremonious opening as Governor Dewitt Clinton rode with a flotilla of boats from Buffalo on Lake Erie to New York City.

The Appalachian Mountains blocked east–west boat travel until the Erie Canal

The Appalachian Mountains, spanning from Alabama to Canada, long hindered inland commerce. The Erie Canal created the first reliable water route through the range by leveraging the natural valley of the Mohawk River, revolutionizing trade and migration.

In 1892, two scientists purposefully infected themselves with cholera bacteria

When they became ill—one with mild diarrhea and the other with severe cholera—researchers pointed to that as proof that the pathogen caused the disease.

The Erie Canal transformed New York City into America’s banking capital

By redirecting western trade through New York Harbor, the canal turned New York into the nation’s commercial hub. This surge in commerce shifted financial power from Philadelphia to Wall Street, establishing the city as America’s banking capital.

The Erie Canal reduced freight costs by 90%

Before the canal, shipping goods overland cost about $100 per ton. After its completion in 1825, rates fell to just $10—making western farm products competitive in eastern markets for the first time.

The Erie Canal runs 363 miles from Albany to Buffalo

Mostly using the low elevations of the Mohawk River Valley, the canal project connected the Great Lakes to the Atlantic seaboard for the first time. This site has a series of old and new maps of the canal.

Grosse Île, the quarantine island of the Port of Quebec

As tens of thousands of Irish emigrated to North America to escape the Great Famine in the mid-19th century, many port cities set up quarantine areas amid an epidemic of cholera. In Quebec City on the St. Lawrence River, one island became a mass graveyard where over 3,000 Irish immigrants died over a decade as they waited in quarantine. Listen to the history here.

Europeans' arrival to America brought disease to Indigenous populations

Indigenous people lived in the Americas for centuries before the arrival of the first Europeans in the 15th century. Their arrival was disastrous for Native tribes; in addition to being enslaved and losing their land, they had no natural immunity to the diseases brought by colonists. Eventually, up to 95% of the Native American population was killed by illnesses including typhus, chickenpox, and cholera, an event now known as the Great Dying.

The original canal had 83 different hand-operated locks

Locks are gated chambers that raise and lower boats between stretches of water at different levels. On the Erie Canal, 83 such locks managed a 565-foot elevation change from the Hudson River to Lake Erie.

Roughly 25,000 workers died building the canal

For each mile of canal that was built, 500 workers lost their lives. The threats came from multiple fronts: mudslides, floods, earthquakes and disease-carrying mosquitoes. Workplace accidents became so common that artificial limb manufacturers competed for contracts with the canal builders.

Explore the technical side of the Erie Canal

Listen to this podcast from Northwestern University exploring the canal’s groundbreaking infrastructure—from locks and aqueducts to its role as America’s first large-scale engineered waterway.

Reflections on the Erie Canal’s 200-year history

Reflections on the Erie Canal traces the waterway from its 1825 opening to its evolving role today. Each short video in this 10-part series explores a different aspect of the canal and its legacy today.

Measles reached global transmission during the 15th- and 16th-century Columbian exchange

Devastating diseases like smallpox, influenza, measles, and other viruses were largely introduced into the Western Hemisphere beginning with the 1492 arrival of Christopher Columbus and the ensuing age of exploration.

The cholera bacteria was first isolated in 1854—but the discovery was largely ignored

The pathogen was isolated by the Italian physician Filippo Pacini in Florence, Italy, though his discovery was largely ignored in favor of the popular miasma—bad air—theory of disease at the time. The pathogen was separately isolated about three decades later by German microbiologist Robert Koch.

Dr. William Gorgas eradicated yellow fever in Panama, crucial to canal construction

The disease was one of the factors hampering the French effort to build the canal. Gorgas' experience elsewhere in the Caribbean had taught him that good drainage and quaranting patients were essential, and he would eventually apply mosquito prevention tactics on a mass scale.

Paris and Boston were redesigned partly to combat cholera's spread

Georges-Eugène "Baron" Haussmann, who oversaw Paris's redesign in the 1800s, replaced many of the city's narrow streets with wide boulevards. This was done at least in part to bring more air and light into the city to help control cholera. Architect Arthur Gilman redeveloped Boston's Back Bay to similarly combat cholera, among other reasons.

Amateur engineers built America’s first great infrastructure project

With no engineering schools in the US, the Erie Canal was designed and built by self-taught amateurs who improvised new methods and became known as the “Erie School of Engineering.”

Infrastructure projects in New York are much more difficult today

The Erie Canal was one of the most ambitious infrastructure projects in American history. Many have said such an effort would be impossible today. This article explores why that is the case and ponders the future of large-scale American infrastructure development.

A bankrupt flour merchant in debtor's prison helped inspire the Erie Canal.

The Erie Canal was built without a single dollar of federal funding

After President Madison and Congress rejected the project, New York State financed the 363-mile Erie Canal entirely on its own—authorizing $7M in bonds in 1817.

We're in the middle of a decadeslong cholera pandemic

In 1961, the world's seventh recorded cholera pandemic started in South Asia, and it has continued through the decades. India and Bangladesh are at particular risk. This pandemic is driven partly by conflict, population displacement, extreme weather, and poor water infrastructure.

Maryland required cholera researchers to fly a yellow warning flag—signifying quarantine dangers in the 1970s

University of Maryland Hospital researchers intentionally infected volunteers with the cholera bacterium in the late 1970s to further their understanding of the disease. They proceeded with this work following the recommendation of a US government panel. (Some users may encounter a paywall.)

Before dynamite was invented, Erie Canal builders blasted rock with gunpowder

Constructed decades before the invention of dynamite, the Erie Canal’s toughest obstacles were blasted through using black powder charges.

Thomas Jefferson dismissed the Erie Canal as 'little short of madness'

When first proposed, President Jefferson scoffed at the idea of carving a 363-mile waterway through wilderness and rock. With no precedent in American engineering, the canal seemed impossible.

Container ships are just a fraction of total traffic via the canal

While more container ships traverse the canal than any other type of ship, vessels carrying dry bulk goods, vehicle carriers, chemical tankers, passenger ships, and more also pass through the Central American passageway.

DeWitt Clinton’s “Big Ditch” gamble transformed New York

Mocked as “Clinton’s Folly” and “Clinton’s Big Ditch,” New York Gov. DeWitt Clinton championed the Erie Canal against skeptics. His political drive secured funding for the project in 1817.

Historically, cholera has repeatedly disrupted the Hajj for Muslims

Outbreaks of the disease throughout the 19th century and the beginning of the 20th, killed thousands of religious pilgrims as they sought to complete this obligatory pilgrimage.

Learn how cholera bacteria sicken humans

Once a person has ingested large amounts of the bacteria, typically through contaminated water, cholera bacteria begin producing and releasing a toxin inside their host. It attacks the mucosal lining of the intestine, making it hard to absorb liquids. This process leads to cholera's characteristic symptoms, like voluminous, watery diarrhea.

Cholera was called the 'Blue Death'

In the mid-1800s—when John Snow identified cholera in London—the disease was known simply as the "Blue Death." That's because blood would thicken in patients' veins when they were struggling with extreme dehydration. As a result, their skin would turn a blueish hue as their blood was starved of oxygen.

Before the Panama Canal, there was the Panama railroad

The first ship to cross the isthmus of Panama went not by sea but by land: The paddlewheel steamship Explorer was taken apart and transported by rail, an effort that generated “more trouble than profit,” according to one account.

John Snow—not the one from 'Game of Thrones'—determined that contaminated water sickened London

His pioneering epidemiology work during an 1854 cholera outbreak mapped out the commonalities between people in London who were getting sick. He discovered that ill people were getting water from the same Broad Street pump. Before Snow's work, the prevailing theory was that bad air sickened individuals instead of cholera-causing bacteria in the water.

See how cholera spreads in a community

This animated video offers a comprehensive look at how cholera spreads. It makes clear why it's so difficult to stamp out this disease in communities around the world. It also details what steps can help control cholera.

Local limestone made waterproof cement for the Erie Canal

In 1818, engineer Canvass White discovered that limestone near Chittenango, New York, could be processed into hydraulic (or waterproof) cement. This breakthrough replaced costly European imports, enabling watertight locks and aqueducts and revolutionizing American construction.

The ancient Egyptians built prototypes of the modern Suez Canal

The idea to facilitate trade between the Mediterranean Sea and the Red Sea and connect the Eurasian continent was apparent even to pharaohs in the second millennium BCE. Though no physical traces remain, contemporary accounts attest to early, shorter versions of the canal, including from Herodotus.

Working conditions on the Panama Canal, built between 1904 and 1914, were abysmal, with thousands of workers dying on the job.

The century of the Panama Canal

The Panama Canal connects the Atlantic and Pacific Oceans through a 51-mile route that transformed global shipping when it opened in 1914. This breakdown covers how it was built, the workers behind its construction, and why its future may be challenged by climate and competition.

1 in 4 people around the world don't have access to clean water

Poor water sanitation puts people at risk of acquiring this diarrheal infection. Cholera infections are on the rise due to extreme weather events and conflict. In recent years there have been cholera outbreaks in locations that hadn't seen the disease in many years, including Haiti.

How a polluted New York City waterway created extremophiles hungry for 'black mayonnaise'

In the 19th century, coal processing plants, oil refineries, a tannery, and other industries lining the Gowanus Canal contaminated its waters with coal tar, sewage, and other pollutants, forming the toxic sludge. Samples taken from the site before clean-up efforts revealed over 450 species of microbes with metabolisms adapted to break down these contaminants.

About 20% of people infected with cholera have severe symptoms

That's according to studies from outbreaks in Bangladesh. Most people who contract the disease have mild or moderate symptoms, or none at all. Yet anyone infected with the disease-causing bacteria can shed the pathogens in their feces for a few days, or even up to around 10, seeding the environment with bacteria.

Budweiser pioneered refrigerated rail transport for its beer in the 1870s

This enabled Budweiser to achieve national distribution long before competitors, fundamentally transforming the US beer industry. It was also among the earliest large-scale adopters to use pasteurization, allowing it to be shipped long distances without going bad.

Drought conditions force fewer ships to sail the Panama Canal daily

In 2023, canal authorities reduced traffic in the canal amid severely dry conditions. These seven infographics from the Woodwell Climate Research Center explain exactly what happened that historically dry October, and how it affected global supply chains.

In the 19th century, ice-cream-related illnesses were somewhat regular in America thanks to vendors' poor hygienic practices.

Extreme weather conditions heighten cholera risks in settings like refugee camps

Runoff from sewage—exacerbated by situations like flooding or extreme rains—heightens this threat. Increasing temperatures also create the ideal conditions for the bacteria to reproduce, increasing transmission risks.

Robert Koch won the Nobel for his tuberculosis work, but he also pioneered cholera research

Koch was one of the first scientists to isolate the bacterium that causes cholera while investigating an outbreak in Egypt in 1883. He went on to advise about rules to control cholera outbreaks, which formed the basis of the disease control approaches and water hygiene techniques still used today.

'Ben Franklin's World' podcast explores the building of the Erie Canal

Historian Janice Fontanella, site manager of the Schoharie Crossing State Historic Site, joined the podcast to recount the engineering challenges, local innovations, and broader impact of constructing the Erie Canal.

More than 4,000 people died from cholera in 2023

This global health threat sickened more than half a million people in 2023 and killed 4,007 people. That's a 71% increase in deaths as compared to a year earlier. (Report only offered in PDF format.)