The iron lung—a simple mechanical ventilator—was first used to treat polio

Jonas Salk developed the first successful polio vaccine—and tested it on himself

The American medical researcher developed the inactivated virus vaccine from 1952 to 1955 and proved that it could prevent disease. He tested the virus on himself and his family in 1954 and then carried out formal clinical trials on more than 1.3 million children.

View this timeline of polio milestones and vaccine development

Polio has a long history in art and medicine, dating back centuries. It includes a representation of an apparent polio survivor with a shriveled leg in ancient Egyptian art. See milestones in the history of polio in this timeline.

Improved 19th-century sanitation meant kids encountered polio later, with worse results

Almost all children likely used to contract poliovirus, but scientists suggest that when infants encountered it very early in life—due to poorer conditions and hygiene—they still had some maternal protection from pregnancy or through breastmilk, so the symptoms were more flu-like.

Pneumonia was once a leading killer before penicillin treatments

In the early 20th century, pneumonia was a top cause of death worldwide, often fatal without effective treatment. Penicillin turned a once deadly infection into one of the most treatable bacterial diseases.

In 1925, the Isolator was a helmet designed to combat procrastination and improve concentration by narrowing a person's field of vision, blocking environmental sounds, and providing oxygen.

The human toll of the Philips' CPAP machine recall

A CPAP machine is an air pressure-generating motor that forces open the airways of those with sleep apnea, a condition that causes nighttime breathing interruptions. In 2021, Philips Respironics recalled millions of machines after finding the device's sound dampening foam was disintegrating, sending potentially dangerous particles and fumes into users' lungs. The company was warned thousands of times about the foam—something they hid from the public and government.

Why helium mixtures are used in respiratory medicine

Unlike the air near Earth's surface, which is primarily composed of oxygen and nitrogen, heliox is composed entirely of oxygen and helium. Because helium is lighter than nitrogen, the lungs do not have to work as hard to push air, easing the uptake of oxygen via a ventilator, mask, or nasal tube.

In the early 20th century, 'baby cages' were popular among parents who believed that putting their children in the cold would build their immunity to minor illnesses.

Dr. Henry Heimlich, famous for his antichoking technique from the 1970s, was a proponent of controversial and discredited approaches, including infecting cancer and HIV patients with malaria to try to trigger a heightened immune response.

A major US-designed polio vaccine was first tested in the Soviet Union

Albert Sabin's live attenuated virus vaccine—requiring two drops in the mouth—didn't garner political support in the US, so it was tested in the Soviet Union in the late 1950s.

The Breathalyzer was originally called the 'drunkometer.'

Live virus vaccines predated polio—that's how we vaccinate against smallpox

Since 1796, smallpox vaccines have used a live poxvirus related to smallpox. Yellow fever vaccines have used a live weakened form of the virus responsible for yellow fever since 1937.

Brain death is a uniquely modern problem stemming from modern ventilators.

The invention of the barometer proved that air has weight

The instrument measures air pressure by creating a partial vacuum—a region with very low density—which serves as the basis for how suction works. Mercury-based barometers were used until 2007, when they were restricted due to mercury's toxicity.

In 1933, the influenza virus was first identified through 'ferret flu' experiments, which proved that the disease was viral—not bacterial.

See photos of ultraviolet light therapy, widely administered in the early 1900s, particularly among children with skin diseases, tuberculosis, rickets, and more.

Light therapy was widely used as a medical treatment for various maladies in the early 1900s before it was replaced by antibiotics.

Interface device implanted into ALS patients restored some of their abilities

Most people with amyotrophic lateral sclerosis, or Lou Gehrig's disease, require assistance with daily life due to loss of motor control. The electrode-coated, stent-like device used motor mapping data and machine learning to translate brain activity into actions.

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

Chinese scientists transplanted a pig lung into a human being in 2025—but it had to be removed.

Polio commonly spreads when virus-laden feces gets into our mouths

This highly infectious disease is transmitted from one person to another, mainly when we eat virus-laden poop particles. Less frequently, contaminated food or water can transmit the virus, or people can be infected via respiratory droplets (from coughing or sneezing).

Before vaccines, there was 'variolation': what was it?

Before the technology behind vaccinations was discovered, some keen observers of medicine around the globe noticed how previous infections could impact future ones. Learn about the techniques early physicians used before they had vaccines.

The board game Candy Land was invented for children quarantined in polio wards.

The virus was officially described for the first time in 1789

Michael Underwood, an English physician and surgeon, was the first to describe the disorder, noting it caused disability in the lower extremities in children. Large-scale outbreaks of the disease were not observed until the late 19th century.

The first neural devices were cochlear implants, designed to treat hearing loss

Neural interfaces connect with our nervous system to restore or enhance abilities, such as hearing or movement. These neuroprostheses have enabled the restoration of mobility, communication, and activities of daily living that might otherwise require a caregiver.

Using artificial wombs to improve preterm infant health outcomes

Researchers at a hospital in the US have successfully used artificial wombs to care for preterm lambs and are now looking at the possibility of human trials. This nine-minute video includes interviews with the researchers and explains the reasoning...

The history of many kitchen appliances involves unexpected discoveries and applications, including wartime radar turned hamster defroster and replacing an 'ice king' with heat-stealing boxes.

The resurgence of Black lung disease in coal miners

Black lung disease is a preventable condition long associated with coal miners who regularly breathe in toxic coal dust. Simple workplace safety procedures make the disease entirely preventable, but cases are rising. Due to lax enforcement of rules, miners in Central Appalachia are increasingly diagnosed with cases stemming from silica dust inhalation.

Only one strain of wild poliovirus continues to infect humans

Three strains of polio used to regularly infect humans, but two of the strains were declared eradicated in 2015 and 2019, respectively. In 2019, world health leaders estimated complete polio eradication—if achieved—would save $14B by 2050.

Poliomyelitis is derived from Greek

Polio, formally called poliomyelitis, comes from the Greek words for gray (polios) and marrow (myelos)—a reference to the spinal cord tissue that, when infected by the virus, causes paralysis.

The treadmill was invented as a machine for prison labor

William Cubitt invented the machine in the early 1800s, imagining prisoners, usually two at a time, would use it to grind grain or pump water.

Humans are the only known reservoir of poliovirus

The virus has not been found in any other species, which makes humans the only known reservoir for polio. In laboratory settings, nonhuman primates have also been infected with the virus, but there's no evidence that they contract the virus in nature.

In 1984, a dying infant lived for three weeks with a baboon heart inside her chest.

See how pig heart valves have been placed in humans since 1965.

A 1954 outbreak at a Boston boarding school allowed scientists to isolate the measles virus and formed the basis for the first measles vaccine.

Paralysis from polio occurs in under 1% of infections

About 1 in 200 cases of infection causes paralysis. For paralysis to occur, the virus travels from the throat, intestines, and gut to infect specific cells within the spinal cord and brain stem that control movements. Within hours of invading the nervous system, paralysis can occur. The virus can be present in bodily secretions and stool for multiple weeks post-infection.

Inactivated polio virus vaccine is the only one offered in the US—it contains no live virus

Inactivated polio virus vaccines cannot cause illness because the virus isn't alive. It's been the only polio inoculation offered in the United States since 2000 and provides almost complete protection

After FDR was paralyzed by polio in 1921, Eleanor Roosevelt became active in politics and supported his political ambitions

FDR contracted polio at age 39 and permanently lost the use of his legs. Eleanor Roosevelt persuaded him to stay in politics, then took on the task of maintaining his public profile—attending events, building relationships, and serving as his "eyes, ears, and legs" across the country.

Experience a century of America's healthcare advances with this medical visualization, tracing a sampling of healthcare innovations from head to toe.

How humans breathe without thinking about it

We breathe without thinking about it thanks to the body's respiratory system and autonomic nervous system, which controls vital functions. Breathing transports oxygen to the body's cells to keep them working and clears the body of carbon...

Their 1901 Wind Tunnel system revolutionized the study of aeronautics

Only the second to be built in the US, the wind tunnel allowed the brothers to study how air moves around more than 200 different wing shapes. This data helped them refine a key math equation, long held as the standard, that had been based only on one wing shape.

Brain implants are restoring movement and communication in early human trials

Several companies developing brain-computer interfaces have begun testing on humans with promising results. These implants have helped reanimate paralyzed limbs and enable communication, though ethical concerns remain about data privacy.

Before transistors, which regulate the flow of electricity, vacuum tubes—glass tubes containing no gas that resemble light bulbs—served as the electronic switches in computers.

Using AI to restore speech 30 years after a stroke

Through a novel surgical procedure involving electrodes implanted in the brain, along with the help of artificial intelligence, a stroke patient is regaining her ability to speak. This technology converts her thoughts into speech through a digital avatar, allowing her to verbally express herself for the first time in decades.

Exploring carbon compound pore structures contributed to improved gas mask filtration

During World War II, the British Coal Utilisation Research Association sought to improve the efficiency of coal as an energy source and studied the effectiveness of charcoal filters to keep soldiers safe. Rosalind Franklin's research there formed the basis of her PhD and led to five scientific papers.

A first-of-its-kind clinical trial taps livers from gene-edited pigs to clean blood

The experimental dialysis-like treatment from United Therapeutics, eGenesis, and OrganOx, is designed to help people with liver failure. The therapy, which involves attaching the modified pig liver externally, filters a patient’s blood so their own livers can temporarily rest and perhaps heal.

Penicillin was hailed as a 'wonder drug' upon its release

When penicillin became widely available in the 1940s, newspapers and doctors alike celebrated it as a “wonder drug” that could cure infections once considered fatal.

Before the invention of transistors, vacuum tubes made radio possible

Discovered by Thomas Edison, vacuum tubes allow electrical currents to travel through empty space. Later modified into a diode—keeping current flowing in only one direction—vacuum tubes allowed electronics to turn alternating current into direct current.

How helium enables MRI machines to look inside organisms

By cooling the machine's magnets with liquid helium to extremely low temperatures, they can generate and maintain powerful magnetic fields that align the hydrogen atoms in living things to point toward a patient's head or feet. A radio pulse nudges these atoms, which realign and induce a measurable signal in nearby electrical coils. These signals are captured in slices and then stacked into a 3D reconstruction.

The Wright Flyer was an engineering breakthrough, and modern aircraft still use the same principles of flight.