DNA cassette tapes could store 36,000 terabytes of data

Storing data in DNA requires converting binary code into DNA's four-base system

Researchers have suggested that DNA's ability to form compact, dense structures justifies investigating its use for long-term, safe data archiving. This system could fit all of the world's data in a single shoebox, though processing each bit into a nucleotide base takes 2 minutes, as of 2024.

DNA computing allows for storage and processing of massive amounts of data

Although costly and less efficient for simpler tasks, as of 2025, DNA could hold 455 exabytes of data with near limitless parallel computation potential in small data centers. Every movie ever made would fit inside the volume of a single sugar cube.

Glowing chemicals allow scientists to read DNA like a barcode

The process of determining the order of nitrogenous bases in DNA involves first cutting the DNA into fragments, which are duplicated multiple times using bacteria. Fluorescently labeled terminator bases are added to fragments, which are sorted by length and read via laser to reconstruct the sequence.

Laser disc technology stores binary data in etched pits and lands

The pits are dips in the LaserDisc, CD, DVD, or Blu-ray surface that do not reflect the laser from the optical drive back to the photoelectric cell, resulting in a coded zero. Lands are reflective plateaus on the surface that code for a one.

Listen to found cassette tapes from around the world

A growing catalog collects tapes discovered in Barcelona, New York, and other locations, featuring digitized audio for easy listening alongside any accompanying visuals or notes. Some audio fragments include voice memos and mixtapes as well.

Strands of DNA can act as biochemical Velcro and fasten two molecules together because the complementary bases that make up DNA strands bond together consistently.

Compression algorithms can reduce file sizes without losing quality by consolidating repeated data or replacing blocks of code with more compact representations, thereby reducing storage demands and improving data transmission rates.

Visualization of printing synthetic DNA

Ever wonder how synthetic DNA is made? Discover how GenScript uses innovative technology to synthesize precise, high-quality DNA at a larger scale than ever before.

The $3B project scientists called 'junk'

In 1990, scientists set out to map all of human DNA. A $3B bet many called "junk." But the Human Genome Project's radical transparency and a race with a private company sped it to completion in just 13 years. Today, that once-contested map underpins nearly every breakthrough in genetics and personalized medicine.

All publicly available DNA sequences are available at GenBank

The National Institutes of Health's database stores comprehensive, annotated DNA sequences as part of the International Nucleotide Sequence Database Collaboration. It encourages unrestricted data access within the scientific community while allowing submitters to retain intellectual property rights over their data.

Watch how DNA is packaged to a 10,000th of its original size in a cell

In humans, the 2-meter (6.56-foot) molecule wraps around spool-like proteins called histones, forming beads—nucleosomes—that fold up into fibers. These fibers—chromatin—form loops through folding that compress into larger fibers, which tightly coil together to form a chromosome.

Despite privacy risks, scientists are using DNA in the air to assess ecosystem health

While DNA in soil and water samples has long been used for such analyses, airborne DNA is being incorporated into such efforts to monitor individual species abundance, detect invasive species, measure biodiversity, and determine the success of conservation actions. Future work may include detecting attacks from biological weapons.

Genes are the basic units of heredity

These segments of DNA—long molecules made of nucleotides that coil into chromosomes—code instructions for making specific proteins, which correspond to different traits. Approximately 98 to 99% of human DNA is non-coding, with functions beyond protein synthesis.

What's behind the cassette renaissance

Cassettes fell out of fashion in the late 1990s as the popularity of compact discs ascended. But in the streaming era, tapes are having a moment thanks to changing audio preferences, the desire for tangible objects, and a healthy dose of nostalgia. This article explores the recent resurgence, asking whether it's the future of music consumption or just another passing trend.

CRISPR-Cas systems act as genetic memory banks for defending bacterial cells

When viruses called phages inject DNA into bacteria, some bacterial species store bits of this DNA in their own genomes. This allows them to recognize and destroy the same virus if it attacks again.

Genomic sequencing is the process of determining the order of nucleotides that make up an organism's genetic information and can be done in about 24 hours or less for human DNA.

In 2025, researchers in the UK began working on developing artificial DNA

The Synthetic Human Genome Project aims to one day construct human DNA, molecule by molecule, in the hopes of creating disease-resistant cells and synthetic chromosomes for study. However, critics warn it may be misused to create enhanced or modified humans.

DNA carries the unique instructions that shape how each person grows and functions

The human genome contains over six billion DNA letters, organized into 46 chromosomes inherited from both parents. Genes—sections of DNA—serve as templates for making proteins, and variations in these sequences can affect how our bodies work or respond to the environment.

Stacking nucleotide molecules like toy blocks helps build DNA's structure

Each nucleotide is made up of a sugar—deoxyribose—a phosphate group, and one of four bases that contain nitrogen. Like building a two-tone, spiral staircase from the ground up, nucleotides are linked one on top of another so that sugars and phosphates alternate. The twisted strands are held together by hydrogen bonds between base pairs.

Bacteria helped scientists realize that DNA was the hereditary molecule, not proteins

Until the mid-1900s, most scientists believed genes were made of proteins, which were known to act as enzymes, hormones, and other chemicals that mediated an organism's traits. The Avery-MacLeod-McCarty and that benign bacteria could be made lethal, where the inherited factor that caused bacterial transformation contained DNA.

Like counting how often a word is repeated in a sentence, forensic scientists can identify people by tallying how often short segments of genetic information repeat in specific parts of a person's DNA—a set of numbers that varies from person to person.

Turing machines consist of an infinite tape, a read-write mechanism and instructions

Based on the information the mechanism reads on the tape, the machine follows the applicable instruction (e.g., if you read a 1, write a 0) and may proceed to the next cell of data. Given enough time and memory, Alan Turing proposed such a machine could perform any computation.

See how a novel gene editing technique called base editing can create changes in a single DNA base, using a more precise targeting approach than CRISPR-Cas9.

DNA may serve as a flame retardant by self-extinguishing some burning materials

When DNA burns, phosphate groups release phosphoric acid, and nitrogenous bases release ammonia. These molecules, along with the sugar in DNA's backbone, shift the combustion reaction toward the formation of intumescent char. This puffy, carbon-rich layer protects open flames from burning the material beneath.

DNA's four-letter blueprint makes the variety of all living things possible

The proteins responsible for cellular functions and an organism's traits are built outside of a cell's nucleus from RNA—single-stranded molecules created by reading the information in DNA. DNA's double-stranded structure makes it more stable and allows RNA to be made from either of its complementary strands.

The oldest DNA recovered so far is 2 million years old

The oldest DNA recovered so far is about 2 million years old and has given scientists an unadulterated peek into ancient history. This nine-minute video explores the findings and implications of the DNA, which was pulled from frozen soil in...

Only 2% of human DNA codes for proteins

The entire human genome contains about 20,000 protein-coding genes, with the rest having initially been categorized as "junk" DNA. However, research since 2003 suggests that this "dark genome" regulates how protein-coding genes are expressed in response to environmental factors encountered by cells.

Recombinant DNA technology turns microorganisms into protein factories

Genes for molecules such as insulin can be inserted into loops of bacterial DNA called plasmids and reinserted into bacteria. Once placed in fermentation tanks, these bacteria use the gene to produce these molecules, which are then harvested and purified for eventual use.

See the history of DNA sequencing

DNA sequencing evolved from manual methods to automated, high-throughput technologies. The Human Genome Project was possible in the first generation of gene sequencing technology with the "chain termination method," which won developer Fredrick Sanger a Nobel Prize.

Think we decoded the genome in 2000? Nope. It was 2022.

Two decades after the draft sequence of the human genome was unveiled to great fanfare, a team of 99 scientists has finally deciphered the entire thing. They have filled in vast gaps and corrected a long list of errors in previous versions, giving us a new view of our DNA.

Watch DNA replicate itself before cell division

In the average adult human, between 50 billion and 70 billion cells die daily, requiring them to replicate their genetic instructions before dividing into new cells. This process relies on various proteins to unwind, read, build, and proofread new strands, with error rates of fewer than one per 1 billion nucleotides.

Synthetic biology transforms cells into custom DNA foundries

At companies like Ginkgo Bioworks, researchers are reprogramming cells to act as workshops that can create custom molecules, such as medicines and fertilizers, by stitching together DNA sequences—often in novel combinations—before inserting them into an organism's genome.

QR codes were developed in Japan in 1994 to fix bar code limitations

These codes store more data than traditional barcodes—up to 1,850 uppercase characters—and can be quickly scanned from any angle thanks to visual indicators like green squares and zebra-striped lines communicating orientation.

Qubits let quantum computers process massive datasets all at once

The quantum phenomena of superposition and entanglement enable qubits to act in 0 and 1 binary states simultaneously and influence each other instantly. These features give quantum computers incredible power, though keeping them stable is a major challenge.

Sony set the standard for cylinder-shaped batteries when it repurposed manufacturing equipment used to make rolls of magnetic recording tape.

See how computer memory really works—from binary bits to modern RAM

The video explains how computers store information as 1s and 0s, how RAM functions as fast working memory, and why systems utilize different types of storage. The video demonstrates how this process enables computers to operate.

Cells translate genetic information into proteins using RNA messengers

Genes are segments of DNA, each composed of a sequence of nitrogenous bases. Within the nucleus, these sequences are copied into a single strand of ribonucleic acid during transcription. This strand leaves the nucleus and is translated by ribosomes into a chain of amino acids that folds into a functional protein.

Nitrogenous bases connect like puzzle pieces due to their shape

There are four bases—adenine, thymine, cytosine, and guanine—which keep the two strands of DNA connected via chemical bonds between them. Connections between thymine and adenine require two hydrogen bonds, while those between cytosine and guanine need three hydrogen bonds. These differences in bond number prevent non-complementary pairings.

Flexible integrated circuits can be built from carbon nanotubes and elastic materials

Stanford researchers arranged the nanotubes in fishnet-like networks that allow deformation without loss of function. The stretchable ICs have been shown to power micro-LED displays and may be used in smart clothing.

The first compact cassette tape was introduced at IFA 1963

At IFA 1963 in Berlin, Philips introduced the compact cassette tape. This new standardized audio format replaced bulky reel-to-reel tape and would go on to dominate home recording and music listening for decades.

The blockchain offers tantalizing possibilities for future use

Think of blockchains as a running list of information, where new details are added to the running chain as discrete "blocks." With crypto, the information contained within each block could be virtually anything, providing flexibility for uses in commerce, legal filings, healthcare records, and more.

Watch how Sanger sequencing kickstarted the first generation of DNA sequencing

Sanger sequencing is a foundational DNA sequencing technology developed in 1977. The Nobel Prize-winning discovery uses fluorescent dyes at the end of DNA chains, which are sorted by length through electrophoresis, to determine the order of nucleotide bases.

The mathematics of quantum-based cryptography, and why existing data is already at risk

Seeing the potential of this technology, some governments and malicious actors are thought to have already started storing encrypted data, in the hopes that quantum computers within the next 10 to 20 years will be able to decrypt it. As of 2022, the National Institute of Standards and Technology had selected four algorithms for inclusion in a quantum-resistant encryption standard.

Nineteen years after its conclusion, scientists finish what the HGP started

The Human Genome Project mapped 92% of the human genome sequence upon its completion in 2003, leaving unreachable DNA regions unmapped. PacBio HiFi DNA sequencing allowed its completion 19 years later, with the additional mapping of 200 million DNA letters.

Around 5 million of our 3 billion DNA letters differ between individuals

Genetic testing examines gene variants to help explain disease symptoms. It explores how genetic differences between individuals can be used to understand risks of developing diseases like Huntington's Disease or passing variants linked to disease onto offspring.

NASA designed the Golden Record using hydrogen to ensure it's universally readable

The Golden Record holds what is essentially a human "time capsule," featuring music, nature sounds, and greetings from around the world. NASA used the radiation period of hydrogen's simplest transition as a baseline to convey timing and structure. The first coded image is included on the cover as a test so aliens can check if they decoded it correctly.

The South American lungfish has the largest known animal genome, with 91 billion base pairs—a set of genetic instructions about 30 times larger than a human's.

How do you sequence a genome?

If the genome is made up of microscopic chromosomes, how do scientists actually sequence it? Here's a 5-minute video explaining one of the most common processes.

The structure of DNA helices comes in three major varieties

The hereditary molecule can take the form of A-DNA, B-DNA, or Z-DNA based on environmental conditions such as ion concentration and humidity—a characteristic identified by Rosalind Franklin. A-DNA is the shortest and widest of the three, while Z-DNA is the longest and narrowest. B-DNA—the most common variety in living cells—is the intermediate.

Dsup slightly unwinds DNA and changes shape to better cling to the molecule

The damage suppressor protein, which is exclusively found in tardigrades, has also been modeled as coating DNA and shielding it from radiation and the toxic byproducts of radiation damage. Dsup may become a fundamental ingredient in future DNA storage technologies.