How chemical bonds between atoms form molecules and large geometric structures

The outermost shell of electrons in an atom dictates how it bonds to other atoms, including those of the same element, and the properties of the materials composed of those atoms.

Distinguishing polar and nonpolar molecules and why charges get distributed unevenly in molecules

Because each element has a unique number of protons and configuration where electrons exist, they attract electrons that are shared with other elements in chemical bonds to varying degrees. When this attraction—electronegativity—varies between two bonded elements, electrons are more likely to be near the more electronegative element and away from the less electronegative element. This can create regions of opposite charge, or poles, and thus polar molecules.

Adhesion molecules and intercellular junctions allow cells to connect together

While some organic structures are mostly composed of non-cellular components (e.g., collagen and calcium phosphate minerals in bones), tissues and organs composed of connected cells rely on specialized proteins and connections to create watertight seals that protect cells within the interior from environmental molecules.

Strands of DNA can act as biochemical Velcro and fasten two molecules together because the complementary bases that make up DNA strands bond together consistently.

An overview of atomic composition, scale, and structure, which is almost all 'empty' space

It takes about 500,000 carbon atoms lined up next to one another to span the thickness of human hair, and over 99.9994% of the mass of each is contained in the nucleus. About 99.999999999999% of an atom's volume lies outside this nucleus, where electrons exist in clouds of probability. Removing these clouds, the Empire State Building would be the size of a rice grain.

As crystals form, their properties and the shapes they take on, including cubic, tetragonal, and hexagonal patterns, reflect the arrangement of their constituent atoms.

Stacking nucleotide molecules like toy blocks helps build DNA's structure

Each nucleotide is made up of a sugar—deoxyribose—a phosphate group, and one of four bases that contain nitrogen. Like building a two-tone, spiral staircase from the ground up, nucleotides are linked one on top of another so that sugars and phosphates alternate. The twisted strands are held together by hydrogen bonds between base pairs.

More than 90% of the atoms in the human body were forged by stars, with almost three-quarters originating from the explosion of massive stars.

Why most atoms do not spontaneously break apart, despite protons repelling one another

At small scales, the strong nuclear force overwhelms electromagnetic repulsion between positively charged particles, keeping the nucleus intact. However, because the force's range is limited, it cannot provide the attraction needed to hold onto protons that are spread out across very large atomic nuclei.

Watch how DNA is packaged to a 10,000th of its original size in a cell

In humans, the 2-meter (6.56-foot) molecule wraps around spool-like proteins called histones, forming beads—nucleosomes—that fold up into fibers. These fibers—chromatin—form loops through folding that compress into larger fibers, which tightly coil together to form a chromosome.

Electricity is produced when the ends of a battery are connected by a conducting wire, triggering chemical reactions that release the energy stored in chemical bonds.

Different types of ice link water molecules together in unique shapes

The ice used to cool drinks—Iₕ—is composed of H₂O molecules arranged in hexagonal structures. This structure forms as ice expands during freezing, providing additional space between molecules, lowering the overall density, and allowing it to float in water. Under sufficient pressure, this spacing can collapse in many ways, creating new forms of ice.

How geometry and uneven charge distribution make some molecules greenhouse gases

Molecules vibrate and rotate with different frequencies based on their elemental composition and shape, which can produce uneven distributions of electrons, as seen in carbon dioxide and water. The resulting unbalanced electric field can interact with electromagnetic waves of the same frequency, causing the molecule to absorb the radiation.

Nitrogenous bases connect like puzzle pieces due to their shape

There are four bases—adenine, thymine, cytosine, and guanine—which keep the two strands of DNA connected via chemical bonds between them. Connections between thymine and adenine require two hydrogen bonds, while those between cytosine and guanine need three hydrogen bonds. These differences in bond number prevent non-complementary pairings.

Nuclear fusion, where the nuclei of two atoms are combined, can produce near-limitless clean energy, but requires extreme conditions to kickstart because of the natural repulsion of atomic nuclei.

The periodic table organizes elements by atomic structure and common properties

Developed by Dmitri Mendeleev in 1869, the arrangement places elements into columns, called groups, if they share the same number of electrons in their outer shell, indicating similar chemical behavior. From left to right across rows, or periods, elements have more protons, as well as corresponding electrons when neutral.

Diamonds have been made from substances such as peanut butter and carbon dioxide, though they can be created from any carbon-rich material under extreme pressure and temperature.

A chemical overview of water, whose uncommon properties help sustain life on Earth

The uneven distribution of charge in water molecules allows them to bond to each other and to surfaces, enabling them to move against gravity, including up plants through roots and stems. These bonds also keep water in a liquid state over a wider temperature range and make it less dense as it freezes. This causes ice to float and form an insulating layer for underwater ecosystems, from which all life originated.

Snowflakes form when water vapor turns directly into ice

Every water molecule has a slightly bent shape due to electron repulsion and regularly forms bonds with hydrogen molecules. When they freeze, they form a six-sided (or hexagonal) lattice, resulting in the six-sided symmetry of snowflakes. As the snowflake falls, more water molecules freeze onto its six sides, forming the unique, beautiful geometric designs.

Build atoms to learn about atomic number, mass number, and charge notations

In this simulation, users can add protons, neutrons, and electrons to create atoms, view their stability and atomic configurations, and identify how the amounts of these subatomic particles are detailed around the abbreviation for the resulting element using AZE notation.

The history of the periodic table and how it hinted at atoms possessing internal structure

In 1869, more than two decades before the discovery of electrons, Russian chemist Dmitrii Mendeleev organized known elements by atomic weight and chemical properties using index cards. His organization revealed previously undiscovered elements and identified patterns in the reactivity of elements, which would later be linked to each element's outermost electron shell. (Some readers may experience a paywall.)

The simple grandeur of atomic theory

Is the universe made up of a continuous substance, or a finite amount of tiny, indivisible atoms? The atomic hypothesis, largely vindicated in the 20th century, was forgotten for nearly 2,000 years after first being formulated by the Greek philosopher Democritus. Learn more about the theory and its implications for science and human life with this reflective essay.

Elements, isotopes, and ions can be identified by the number of protons, neutrons, and electrons within the atoms that make up a substance.

By organizing elements by atomic weight, Dmitri Mendeleev created the periodic table

The organization included groupings based on similar chemical properties and patterns in atomic weights. This left gaps that were used to predict the properties of elements yet to be discovered—including germanium and gallium—with high accuracy.

Besides the periodic table, there are over 1,000 alternative ways to organize the known elements, with many arrangements emphasizing specific trends among them.

Cooling silica nanoparticles lets physicists push the boundary of how large an object can still behave quantum mechanically.

The characteristic zigzag of lightning originates from columns of conductive oxygen

Energized electrons from the base of clouds collide with oxygen molecules, placing them in a "singlet delta state," which makes the air conductive. Collisions continue until more than 1% of nearby oxygen is in this state—about 0.00005 seconds—matching the electrical potential of the cloud and propogating electricity in a 50-meter "step."

Although burning most objects causes them to lose mass because some of their solid material turns into gas, metals become heavier when burned because they absorb oxygen.

The history of chemistry up to World War I, from alchemists seeking gold to probing atomic structure

Those involved in the predecessor of the modern scientific discipline engaged in experimentation to develop recipes that would transform ordinary matter into gold and to create medicines, cosmetics, dyes, and alloys. Over the course of centuries, scientists identified unique elements, organized them based on their properties in the periodic table, and eventually developed the technology to discover the internal structure of atoms.

Certain objects are magnetic because their electrons' magnetic moment—an intrinsic quantum property—align within the object in specific patterns.

Visualizing the chemistry of nuclear weapons

Nuclear weapons have devastating effects, but the science of how they work is atomically small. There are two main types of nuclear reaction: fission and fusion. The fission bomb produces immense energy by splitting an atom, the result of firing a...

How brain cells carry information

At any moment, there is an electrical storm coursing through your body. Discover how chemical reactions create an electric current that drives our responses to everything from hot pans to a mother’s caress.

Nanotechnology refers to the study of objects measuring 1 to 100 billionths of a meter, which has produced materials with unique properties by manipulating the arrangement of atoms.

Neurons send signals through electrical impulses and chemical messengers

By converting electrical signals into chemical messages at synapses, neurons allow information to travel throughout the nervous system. With repeated use, synapses grow stronger, enhancing the associations between neurons.

Explore how excitatory cells, such as neurons and muscle cells, transmit information in the body via electrochemical signals, which can travel up to 120 meters (390 feet) per second.

Smaller than atoms—what are quarks?

One of humanity’s eternal questions surrounds what we are fundamentally made of. Many ancient philosophies believed in a set of classical elements: from water, air, fire and earth of ancient Greeks; to…

While atoms are normally made of protons, neutrons, and electrons, exotic ones have been built with antimatter—alternate versions of normal matter that live for fractions of a second.

DNA computing allows for storage and processing of massive amounts of data

Although costly and less efficient for simpler tasks, as of 2025, DNA could hold 455 exabytes of data with near limitless parallel computation potential in small data centers. Every movie ever made would fit inside the volume of a single sugar cube.

Visualize what happens to atoms during nuclear fission and how the process produces energy

Nuclear fission occurs when an unstable, often massive, atomic nucleus splits into smaller ones—daughter atoms—and releases energy. Within a nuclear reactor, these daughter atoms can collide and combine with neighboring atoms, destabilizing them and triggering a chain reaction of atomic splitting.

Why water is the universal solvent, despite not being good at dissolving many substances

Because oxygen attracts electrons much more strongly than hydrogen does in H₂O, the molecule is polar, with a negative charge at the oxygen atom and positive charges at the hydrogen atoms. These charged regions can attract and pull apart charged portions of other polar molecules, such as washable inks, but are unable to dissolve nonpolar materials, such as glass and asphalt.

The structure of DNA helices comes in three major varieties

The hereditary molecule can take the form of A-DNA, B-DNA, or Z-DNA based on environmental conditions such as ion concentration and humidity—a characteristic identified by Rosalind Franklin. A-DNA is the shortest and widest of the three, while Z-DNA is the longest and narrowest. B-DNA—the most common variety in living cells—is the intermediate.

How a quantum quirk allowed neutral atoms to form soon after the Big Bang

At the beginning of the universe, high-energy photons prevented atomic nuclei from combining with electrons to form neutral atoms. Rather than waiting for the universe to expand and cool completely, a rare quantum phenomenon—a two-photon transition—allowed neutral hydrogen atoms to form sooner, expediting the formation of stars, planets, and life.

Metals can be welded together in space without needing heat

On Earth, oxygen naturally reacts with metals to form an oxide layer on their surface, which prevents two different pieces from fusing when they come into contact. If the layer is worn away without oxygen to replenish it, metals can instead stick together upon impact—a phenomenon known as cold welding.

Complex molecular reactions in our tissues cause muscle contraction

When we want to move a muscle, a signal travels from the brain and into the muscle cells in question, sparking a chemical reaction that causes the muscle's smallest contractile units—sarcomeres—to shorten, forcing the muscle to contract.

Fusion reactions and radioactive decay produce elements inside stars

Hydrogen, present since the early universe, serves as fuel for the proton-proton chain, producing helium, which is then incorporated into the CNO cycle to produce carbon, nitrogen, and oxygen. Additional fusions of helium with these elements and subsequent decays via the alpha ladder produce elements up to iron and bismuth.

While both are nuclear weapons, atomic bombs release nuclear energy by splitting large atomic nuclei, whereas hydrogen bombs derive most of their energy from fusing heavy hydrogen isotopes.

During manufacturing, lithium-ion and alkaline batteries are tested for short-circuiting

Lithium-ion batteries are made by manufacturing anodes, cathodes, and electrolytes via chemical processes, assembling these components into cells, and enclosing multiple interconnected cells within a protective casing. Disposable alkaline battery production involves filling steel containers with preforms—rings of powdered cathode material—paper-based separators, electrolyte solution, and an anode gel.

Lithium can store and deliver substantial energy for its cost and weight

When exploring which compounds would be best suited for batteries, scientists sought elements that were relatively inexpensive to mine, readily available, and that provided high energy density—how much chemical energy an element could store for its size. Lithium-ion batteries provide these benefits and discharge at very low rates when unused.

View 3D renderings of atomic orbitals created with quantum mechanics

Scientists use the Schrödinger equation to determine how a system governed by a wavefunction—an equation that predicts the probability of certain outcomes—evolves with time. Computers can animate atomic structure and behavior by depicting the wavefunction as a fluid that guides a particle, like water moving a speck of dust.

What is gravity made of?

Our world at very small scales is governed by quantum mechanics, in which forces and energy come in discrete packets. At large scales, our world is governed by gravity, which moves the planets and stars and can create waves in spacetime. To merge...