Complex molecular reactions in our tissues cause muscle contraction

One of the leading theories behind muscle movement

According to the Sliding Filament Theory, skeletal muscle contraction is made possible by sarcomeres, which are made of bundles of myosin and actin proteins inside muscle cells. Myosin pulls itself along actin to contract a muscle, shortening the muscle and its cells and enabling physical movement. It then releases its grasp on actin so it can start the process over again if so commanded.

Myokines are molecules that facilitate some of the benefits of exercise

When muscles contract, they release ‘hope molecules’ (myokines) such as IL-6 and irisin. These proteins then travel through the bloodstream to reduce inflammation, improve insulin sensitivity, and even support brain repair. This piece illustrates how movement triggers a systemic healing cascade throughout the human body.

Muscular system explained

Skeletal, cardiac, and smooth muscles form the system that powers movement, survival, and daily life. Skeletal muscles are voluntary, enabling conscious actions like lifting or walking, while cardiac and smooth muscles are involuntary, controlled by the autonomic nervous system. From every heartbeat to each breath, these three muscle types work in harmony to keep you moving, thriving, and alive.

Muscles fatigue due to the loss of energy like ATP and glycogen

Adenosine triphosphate fuels muscle contraction, and with each contraction (like during exercise), the amount of ATP reduces. ATP helps potassium and sodium move across muscle membranes, generating ions and helping to contract the muscle.

What does the muscular system do?

The muscular system is responsible for movement by and throughout the body. Smooth muscle contractions push food and blood through the digestive tract and blood vessels, respectively. Skeletal muscles are responsible for voluntary movement or lack thereof by the body. Cardiac muscle controls the beating of the heart, which is the pump that powers the circulatory system responsible for distributing energy and nutrients to cells across the body.

How brain cells carry information

At any moment, there is an electrical storm coursing through your body. Discover how chemical reactions create an electric current that drives our responses to everything from hot pans to a mother’s caress.

How does muscle memory work?

Muscle memory is less about remembering how to ride a bike and more about what's happening in muscle cells. Increasing the cells' size, say by working out, leads to an increase in nuclei, which increases the production of mitochondria. When your fitness regimen falls to the wayside and you decide to re-enter the gym, these gains-based nuclei are already present to quicken muscle cells' adaptation to exercise.

Exercise can lead to muscle microtears, but the body's repair systems cause those fibers to grow back larger.

Explore how excitatory cells, such as neurons and muscle cells, transmit information in the body via electrochemical signals, which can travel up to 120 meters (390 feet) per second.

What is the muscular system?

The muscular system comprises three distinct types of muscle: smooth, cardiac, and skeletal. Cardiac muscles make up the heart, whereas smooth and skeletal muscles are found throughout the body. Smooth muscles line blood vessels and most organs, and skeletal muscles are responsible for moving the body or holding it stationary. All muscles are made of muscle cells or fibers, which give them the ability to contract.

Neurons send signals through electrical impulses and chemical messengers

By converting electrical signals into chemical messages at synapses, neurons allow information to travel throughout the nervous system. With repeated use, synapses grow stronger, enhancing the associations between neurons.

Metabolism, a collection of chemical reactions at the cellular level, processes food and converts it into energy to power the body.

Physiological muscle memory allows us to quickly regain lost musculature

The term "muscle memory" is most often associated with the neurological kind, which involves the development of strong and efficient neural pathways in the brain and spine. Physiological muscle memory also slows the loss of muscle mass, with both types affected by genetics and diet.

Food passes through the digestive system via muscle movement known as peristalsis, a rippling contraction that pushes food onward through tubular organs.

How skeletal and smooth muscles differ

Skeletal and smooth muscles are two of the three muscle types found throughout the body. The former is attached to bones via tendons, enables limb movement, and is consciously controlled. The latter is found lining blood vessels and hollow organs (e.g., the intestines, stomach, and esophagus) and is managed by the autonomic nervous system, which means it's outside conscious control.

How ALS (Lou Gehrig's Disease) might work, and what scientists are learning about it

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the nerve cells (neurons) controlling muscle movement. As the motor neurons degenerate, they stop sending signals to the muscles, causing progressive muscle weakness and, eventually, death. This three-minute animation focuses on the mechanisms within the motor neurons that cause them to degenerate. By understanding these mechanisms, researchers hope to one day find a cure for ALS.

Neural rhythms shape how we move, focus, remember, and interact with the world

Millions of neurons in the brain produce rhythmic electrical signals, or brain waves, that guide physical movement and help form and store memories. Researchers also use these rhythms to create brain-computer interfaces, letting people control devices using only their thoughts.

Exercise releases chemicals that enhance cognitive function

Neurotransmitters like dopamine, serotonin, and norepinephrine, along with increased brain-derived neurotrophic factor levels, enhance a wide range of brain functions. New research demonstrates a direct link between movement and numerous cognitive benefits, including memory, learning, and stress resilience.

Adhesion molecules and intercellular junctions allow cells to connect together

While some organic structures are mostly composed of non-cellular components (e.g., collagen and calcium phosphate minerals in bones), tissues and organs composed of connected cells rely on specialized proteins and connections to create watertight seals that protect cells within the interior from environmental molecules.

Exercise can change your genes without changing your DNA.

'Viscoelasticity' allows muscles to be elongated briefly after stretching

The protective tissues around skeletal muscles consist of elastic proteins like collagen. Stretching them expands their length while retaining strength, ideal for athletes.

The anatomy of our hair follicles explains goose bumps

The arrector pili muscle contracts when we're cold or scared, causing hairs to stand up and the skin to form the bumps known as goose bumps. This reaction is typically involuntary.

Explore how cells respond to signals from their environment

In "Dropping Signals," users can drag stimuli, such as hormones and light, into various cellular environments to observe cellular responses. These include changing their shape, enabling the transport of chemicals into or out of the cell via the cell membrane, or dividing to compensate for surrounding damaged cells.

How muscles get their names

There are more than 600 muscles that crisscross the human body, and each has a name that's more than a simple label. Muscle names also typically communicate the muscle's size, behavior, length, location, appearance, direction, and attachments to bone. These names usually have Greek or Latin roots, such as in the case of the deltoid muscles, which are named in reference to the Greek letter delta (𐤃).

Why do dreamers twitch?

This thought-provoking piece highlights newer research suggesting sleep twitches may not be random dream leftovers, but instead a crucial way our brains map and understand our bodies. From sleeping rat pups to dreaming octopi, this biological mapping system appears universal across animal species.

The reason some people love exercise may be because of their microbiome

Certain gut microbes in mice trigger dopamine release and drive motivation to exercise more. Scientists are investigating whether humans carry similar microbial patterns that influence our natural inclination towards movement, exploring how unseen microbial ecosystems may shape mammalian fitness behavior and reinforce innate reward pathways. (Some users may experience a paywall.)

On average, the human body produces about 100 watts of electricity—enough to power a light bulb—but some people can produce over 2,000 watts in short bursts, such as when sprinting.

Explore 1,800+ exercises with an interactive muscle map that lets you click any muscle to see targeted exercises, including video tutorials and written instructions.

Why do you shiver when cold?

Humans are warm-blooded creatures, so our bodies like to maintain internal temperatures separate from and typically above those in their environment. This is made possible by a process known as thermoregulation. When the brain's hypothalamus senses a drop in the body's core temperature, skeletal muscles may be ordered to shiver, sending out waves of muscle contractions and exothermic biochemical reactions whose byproduct includes heat and energy.

Why does the body have a stress response?

When encountering a stressful situation, the human body typically goes into what is known as "fight-or-flight" mode. Because it evolved as a survival mechanism, the biochemical response enables people and other mammals to react quickly to life-threatening situations. The carefully orchestrated yet near-instantaneous sequence of hormonal changes and physiological responses helps someone to fight the threat off or flee to safety.

Goose bumps are often triggered by emotions

A physiologist and professor of zoology explains that the subconscious release of adrenaline, a stress hormone, causes a contraction of skin muscles. It’s released in several situations, including when humans are cold, afraid, or feel strong emotions. (Some readers may experience a paywall.)

Stress activates the "fight-or-flight" response when we face threats, a reaction that can help keep us alive.

Explore an interactive 3D model of the brain

The brain contains about 86 billion neurons—nervous system cells—and controls vital bodily functions via electrochemical signals. Neurons form circuits through axons, and different brain regions use these circuits to perform specific tasks.

Humans likely cannot tickle themselves because there's no element of surprise

Unraveling the neural mechanisms of tickling—formally called gargalesis—is an area of active research, but a leading theory about why we can't tickle ourselves is that the brain's somatosensory cortex processes self-touch differently than it does external touch. The cerebellum already anticipated what was going to happen when you move your hand for self-touch, limiting the effectiveness of a self-tickle.

Internal-combustion engines convert fuel into motion using controlled explosions

Gasoline engines mix fuel and air, compressing it and igniting it to create thousands of tiny explosions that push pistons up and down. This movement spins the crankshaft, which moves a vehicle's wheels.

Human anatomy 101: the body's systems

Human life is made possible by the body's ten major systems, which maintain homeostasis by responding to incoming sensory and biochemical input. Each system must work independently and collaboratively for the body to maintain health and respond appropriately to its internal and external environments. The bones of the skeletal system, for example, give the body its shape and protect organs while also facilitating movement with the muscular system.

How neurons give rise to thoughts

Neurons in the brain are singular nerve cells that flicker on and off or connect to each other based on incoming stimuli. The more neurons communicate by firing electrical impulses through tendrils known as synapses, the stronger their connection becomes. The electrical energy zipping along these interneural connections in an attempt to classify and respond to incoming stimuli may be what gives rise to thoughts.

As immobile animals, corals and the organisms that live on them have evolved a suite of chemical compounds to prevent disease and ward off predators they cannot outrun.

How chemical bonds between atoms form molecules and large geometric structures

In ionic bonding, one atom transfers at least one electron to another atom, forming two atoms of opposite charge. These atoms attract one another and can stack up in a 3D grid called a lattice. Covalent bonding, where electrons are instead shared, can produce enormous molecules, such as the two found in human chromosome 13, which each contain 37 billion atoms.

Take a deep dive into the neuron

Neurons are the basic unit of the brain and nervous system—electrically excitable cells that sends signals throughout the body. They can communicate with each other, fire in sequence, and conspire to do everything from drive body movement to help form memories. Check out this intro-level overview to learn more about their structure and how they work.

How trauma gets ‘under the skin’

A study examining the muscle function of older adults who have at least one adverse childhood experience (ACE) suggests that trauma digs itself into muscle cells. Participants who reported childhood trauma were found to have lower maximum levels of cellular energy than people who reported fewer or no ACEs. Such compromised mitochondrial function "doesn't bode well," as it relates to a variety of health and age-related outcomes.

Itching is caused by stimulated nerve cells in the skin

Scratching produces low-level pain signals to the brain, distracting from the itch. Scratching also releases serotonin, a neurotransmitter that creates a happy sensation, which resets the itch signal. This can cause a cyclical itch-scratch cycle.

Electricity is produced when the ends of a battery are connected by a conducting wire, triggering chemical reactions that release the energy stored in chemical bonds.

Strength training appears to make for a healthier, youthful-looking brain.

Stress-induced adrenaline can trigger a 'hysterical strength' response

The stress response is a powerful ancient mechanism designed to maximize human survival—it can even result in superhuman strength. The adrenal glands are located just above the kidneys, and stress-induced adrenaline release causes more blood (and therefore more oxygen) to flow to your muscles, increasing performance.

Snakes move around by coordinating hundreds of muscles

These muscles connect to their vertebrae, and allow the creature to move in various unique ways. Snakes can slither, move in a straight line, swim, jump and even "fly."

Learn how your body is, scientifically, like a firework with its own slow, controlled burn.

Optimal human functioning requires movement

There is now ample evidence to back the centuries-old hypothesis that exercise is critical to human health. This review article explores the latest discoveries in exercise science, including how exercise is intrinsic to maintaining our organ systems throughout life.

Cells modify their internal spacing to improve biochemical reaction efficiencies

Studies involving microscopy and genetic engineering tools in yeast and human cells show ribosomes act as crowding agents—much like packing peanuts—and their concentrations are actively tuned to alter the rate of cellular functions. However, these concentrations and cell crowding levels vary across different tissues and cell types.

What happens when we sleep

Sleep is a highly specialized and complex process that begins via signals from a region of the brain called the hypothalamus. As explained in this overview video from The Economist, the hypothalamus maintains our circadian rhythm by using light cues from our environment to regulate sleep via a compound known as melatonin. Once asleep, the brain begins the "sleep cycle" and progresses through the four stages of sleep over and over again each night.