Research studies can be conducted inside or outside of living samples

IVF procedures fertilize eggs outside the body in a laboratory dish

In vitro fertilization is a complex and expensive set of procedures that potential parents dealing with infertility or genetic disorders may turn to when other methods are unavailable. IVF births account for 2% to 3% of all live births in the US annually.

Model organisms like yeast, mice, and flies help scientists decode the human body

Some species are used to quickly study the effects of human diseases and treatments because they are short-lived and have similar systems to those found in humans. Bacteria, like E. coli, have been used as human proxies given their rapid growth and ease of genetic manipulability.

Gene therapy can occur inside the body, but it can also be completed outside the body—with scientists treating cells in the lab, and then those corrected cells are transplanted back into the body.

Scientific advances are unlocking a wide range of alternatives to IVF

From refined artificial insemination and microsurgical sperm extraction to experimental uterine transplants, scientific innovation is rapidly advancing potential fertilization technologies. But they come along with costly trials, some ethical dilemmas, regulatory issues, and more.

Scientists William Russell and Rex Burch proposed in 1959 that when it comes to animal testing, there should be 'three Rs'—replace animals wherever possible; reduce their numbers; refine how they're treated.

In vitro gametogenesis: using induced stem cells to fertilize eggs

Using stem cells from skin and mouth cells could save hopeful parents time and money and spare egg donors from significant amounts of discomfort throughout the process. There are potential consequences, not just for infertility treatment, but for the ability to create customized cells of any type.

Bioluminescent reaction enzymes are often used in biomedical research

Near-infrared luciferase systems allow researchers to image and analyze cellular activity in living animals because they penetrate tissue more deeply than visible light. This provides a means of studying gene expression and protein interactions without harming the animals.

Advance genetic research by playing these scientific video games

Computers produce so much information that researchers can't properly analyze all the data produced, and the overload can also lead computers to make mistakes. Researchers are increasingly turning to citizen scientists—members of the public who are willing to volunteer—to help them make sense of data when computers can't. This article details a few of the ways you can contribute to genetics research by playing video games.

De-extinction techniques create new species from existing organisms

Rather than recovering a genetic sample of a lost species and editing it with that of living creature—as has been depicted in science fiction—scientists begin with living cells from close genetic relatives and use tools like CRISPR to swap in extinct versions of specific traits to create new hybrid species.

View a breakdown of bioremediation strategies, divided into onsite and offsite options

Depending on the contamination's complexity, in situ—onsite—options may be preferred and can include supplying oxygen or nutrients into the existing soil to accelerate the microbial breakdown already present in the environment. Ex-situ methods instead displace contamination for treatment away from the environment and may be used for volatile chemicals that require isolation, though this displacement can also spread contaminants if spilled.

Organoids: 3D organs grown from stem cells in the lab

An organoid is a three-dimensional construct composed of multiple cell types that originate from stem cells that can simulate the architecture and functionality of native organs. One big benefit of these lab-grown organs is that drug candidates can be tested in model systems without needing live patients.

Despite privacy risks, scientists are using DNA in the air to assess ecosystem health

While DNA in soil and water samples has long been used for such analyses, airborne DNA is being incorporated into such efforts to monitor individual species abundance, detect invasive species, measure biodiversity, and determine the success of conservation actions. Future work may include detecting attacks from biological weapons.

How do brain scans work?

There's only one thing in our solar system sophisticated enough to study itself: the human brain. But this self-investigation is challenging because a living brain is shielded by skull, swaddled in tissue, and made up of billions of tiny cells. How do we study living brains without harming their owners? Two experts explain how the various techniques like EEGs, fMRIs, and PETs work in this TedEd talk.

Some medical schools have phased out human cadavers for digital alternatives

AI-based anatomy tools and digital cadavers are increasingly used to teach students, bypassing the ethical and consent concerns around the use of real bodies. Digital cadavers have also become less expensive than real ones, though the tactile and sensory experiences of real dissection may be irreplaceable.

Scientists are experimenting with ways to probe the multiverse theory

Researchers are simulating vacuum bubbles—the theorized starting points of universes—using quantum computers, digital models, and exotic lab setups to study how they form, expand, and possibly collide. One experiment aims to "blow" artificial universe-like bubbles inside ultra-cold quantum gases, potentially capturing real-time glimpses of cosmic birth processes in a lab.

How 3D printing inside cells paves the way for microscopic machines

In 2026, scientists in Slovenia developed a method to 3D print a small elephant, several microscopic geometric objects, and barcodes for cell labeling within living human cells, which continued to grow and divide thereafter. The experiment opens the door to fabricating devices within cells to study and manipulate cellular functions.

Scientists can tag distinct proteins with fluorescent probes that emit different colors, allowing them to visualize multiple biochemical processes simultaneously.

Inside the community movement behind DIY synthetic biology

Margaret Talbot spotlights the rise of DIY biology in community labs, where amateur scientists—often outside formal institutions—create everything from insulin to prosthetic prototypes. These grassroots biohackers challenge traditional science by pursuing open, accessible innovation, raising questions about credibility, ethical oversight, and acceptance by mainstream researchers.

A step-by-step overview of the IVF process

In-vitro fertilization involves a sequence of complex steps to move from egg production to birth. This include stimulating egg production in the ovaries, egg harvesting and fertilization outside the body, embryo culturing and transfer, and methods to support in and increase the likelihood of full-term pregnancy.

You can sign up to donate your body to science

It's a separate process to donate your body for medical research; you usually must contact a whole-body donation program directly. Bodies can be donated for medical research, for forensic analysis research, or for medical students to work with as they learn anatomy and surgery, among other purposes. Learn more about numerous accredited organizations that provide human bodies, organs, and tissues to medical researchers and students.

Synthetic biology can prevent extinction by creating create disease-resilient plants and animals

Through gene editing and the deployment of artificial cells, scientists can leverage learnings from the genetic sequencing of animals with known resistances to protect endangered species. Gene editing of certain species, such as mosquitoes, can also reduce their ability to spread diseases like malaria between humans.

Explore how cells respond to signals from their environment

In "Dropping Signals," users can drag stimuli, such as hormones and light, into various cellular environments to observe cellular responses. These include changing their shape, enabling the transport of chemicals into or out of the cell via the cell membrane, or dividing to compensate for surrounding damaged cells.

Synthetic biology transforms cells into custom DNA foundries

At companies like Ginkgo Bioworks, researchers are reprogramming cells to act as workshops that can create custom molecules, such as medicines and fertilizers, by stitching together DNA sequences—often in novel combinations—before inserting them into an organism's genome.

Comparing bioremediation with other treatment techniques, at three levels of complexity

Physical manipulation, such as collecting and moving contaminated material to a landfill, or chemical applications, which use strong, expensive substances and produce harmful byproducts, can be costly. While bioremediation leverages naturally occurring degradation processes that can be augmented without disrupting impacted ecosystems, these processes may be less effective in environments that bioremediation organisms are not adapted to.

Each scientific study adds incremental knowledge to existing understanding

On its own, no study serves as a source of truth or solves an existing problem indefinitely, though many can be analyzed collectively in a systematic review to build more confidence—the result of more data—in a conclusion. Studies can explore knowledge gaps or test an existing theory, which is always subject to refinement and improvement.

Scientists can suck animal DNA from the air

A look at how researchers filtered the air around two zoos and identified genetic material from dozens of species, a technique that could help track and conserve wildlife.

The secret lives of cells

Cutting-edge microscopy has revealed previously unseen interactions of biological molecules within their cellular environment, enabling scientists to observe and analyze the molecules in a holistic view. This podcast explains the minute advancements made over the last few decades in observing cells, revealing how scientists have come and what the future holds for the field.

Environmental DNA monitoring can help detect the presence of invasive species

Genetic material that organisms deposit into water, soil, or air can be identified by analyzing samples from each environment, allowing land managers to more reliably detect and track organisms than visual surveys alone. eDNA has been used to develop early warning surveillance systems for various invasive marine species.

IVF was long considered controversial and ethically dubious

In spite of its wide acceptance as a form of reproductive assistance today, and its role in helping millions of people have children, in vitro fertilization was once considered a controversial threat to society. One magazine went as far as to describe the procedure as "the biggest threat since the atom bomb."

As of 2025, perfect synthetic replication of natural organs remains elusive

Advancements such as 3D printing muscles, performing vaginal reconstruction with colon tissue, and growing organs in a lab have shown promise, but artificial options and transplanting substitutions continue to exhibit functional and performance limitations compared to their natural equivalents.

Explore the differences between healthy and cancerous cells using a DNA microarray

In this simulation, you will learn how scientists use microarrays to experiment on thousands of genes at the same time. By determining which genes are on or off, users can identify those that contribute to cancer formation.

US federal researchers are blocked from putting certain human cells in animals

In 2015, US policymakers put a halt to any government-funded work that would insert human stem cells into animals. The reasoning was that human cells might spread through the animal's body and perhaps to its brain, blurring the line between humans and nonhumans. The ban remains in place today even as gene-edited pig parts are being placed in humans.

Is synbio really cool, really scary, or both?

There's always been a divide between technology, the inanimate stuff that we build, and biology, the living stuff that nature builds. Synthetic biologists are trying to figure out how to close the gap by building living things.

Follow an IVF procedure from lab to transplant

What happens once eggs are harvested from an ovary? How does an embryo form within a petri dish? This detailed video offers a glimpse of the transformations eggs experience as women age, and how sperm are injected into eggs in some forms of IVF treatment.

The challenges of trying to study microplastics in microplastic-abundant labs

The presence of microplastics in instruments, surfaces, and air has made accurate measurement of their levels in lab samples difficult, given the high likelihood of contamination. While the use of stainless steel tools in a sealed, clean lab may reduce accidental exposure, existing methods can misidentify biological substances, such as fat, as plastics, further complicating research.

Humans experience the world subjectively. What does that mean for scientific research?

When you close your eyes, do you see static or colorful patterns or an "intrinsic grey" known as Eigengrau in German? This variation of our internal experiences is just the tip of the iceberg, one that scientists are increasingly studying and...

Humans need vitamins, but research is mixed on taking supplements

When an organism needs an organic molecule to survive, but cannot synthesize enough of it itself, that molecule is called a vitamin. Typically, we consume vitamins through food, but many resort to supplements—a common and mostly unregulated practice.

Living donations most commonly involve a kidney or part of a liver

In 2023, more than 6,900 transplants were made possible thanks to living donors. Living donation is when a living person donates an organ or part of an organ—usually one of their two kidneys or part of the liver, since that organ can regenerate in a healthy person. Much more rarely, living donors donate other organs. Living donations often occur when someone wants to ensure a loved one has certainty that they will quickly receive a needed organ.

Long-term evolution experiments use microbe's short generations to speed up selection

With quick generations of microbes, scientists can speed up the evolutionary process, with projects like the LTEE in California running for 40 years and generating 80,000 generations of E. coli.

Schizophrenia is being studied with pea-sized 'mini-brains'

Brain organoid research is enabling researchers to study distinct electrical firing patterns associated with schizophrenia. These "mini-brains" that are constructed in the lab from patients' cells could lead to better diagnosis approaches and drug development.

Challenges for synthetic biology

Can engineering approaches tame the complexity and unpredictability of living systems? An exploration of five challenges for the field and how they might be resolved.

Why scientists are making robot insects

Insects have much to teach us about flying, jumping, moving quickly, and more. So, roboticists are studying how insects do the ridiculous things they do, like walk on water or jump fifty times their body height, to inform their design and engineering of a new slate of robots: tiny ones. Learn the future of this type of robot with this fascinating video with insights into both insects and robots.

Microbial research suggests shifts in diverse populations may help an invasive species establish itself

In 1958, English ecologist Charles Elton suggested that diverse ecosystems should be more resistant to invasive species because gaining a foothold would be more challenging when resources are more thinly spread. However, in lab-grown microbial ecosystems with greater biodiversity, population volatility opened more ecological roles that invasive species could easily fill.

Epigenetic editing—altering gene expression by removing or adding chemical groups on DNA—is making significant strides in the lab, even lowering cholesterol in monkey experiments by about 70%. (Free w/email.)

'Immortal' HeLa cells—cancerous cells widely used in biomedical research after they were nonconsensually taken from a Black woman named Henrietta Lacks—proliferate easily, causing millions of dollars of damage annually by contaminating lab cell cultures.

Biohacking to boost personal health has become a concept that encompasses everything from vitamin regimens and cryochambers to brain implants and red light therapy.

Pig-to-human transplant work has raised concerns about donor pigs' living conditions.

Animal brain studies show brain activity similar to what we'd expect during dreams, but parsing whether animals are truly dreaming depends on how one defines dreaming and how scientists could prove it.

What conditions can be treated with stem cells?

Stem cell research is a global enterprise, and much of the work is being done in Europe. This page gives readers a good sense of the medical conditions stem cell researchers in Europe focus on, and the specific research challenges they address. This page also offers links to in-depth information about many of the research projects.

Scientists have created a cell from scratch—called a SpudCell—proof-of-concept work that a lab-made cell can feed, grow, and replicate like a natural cell.