Muscles fatigue due to the loss of energy like ATP and glycogen

Why death is caused by a dearth of ATP

Though people die from many causes, this video makes the case that a lack of adenosine triphosphate production in the body is what kills almost all of us. Without ATP, physiological processes grind to a halt, and organs stop functioning.

Exercise can lead to muscle microtears, but the body's repair systems cause those fibers to grow back larger.

Complex molecular reactions in our tissues cause muscle contraction

When we want to move a muscle, a signal travels from the brain and into the muscle cells in question, sparking a chemical reaction that causes the muscle's smallest contractile units—sarcomeres—to shorten, forcing the muscle to contract.

One of the leading theories behind muscle movement

According to the Sliding Filament Theory, skeletal muscle contraction is made possible by sarcomeres, which are made of bundles of myosin and actin proteins inside muscle cells. Myosin pulls itself along actin to contract a muscle, shortening the muscle and its cells and enabling physical movement. It then releases its grasp on actin so it can start the process over again if so commanded.

Myokines are molecules that facilitate some of the benefits of exercise

When muscles contract, they release ‘hope molecules’ (myokines) such as IL-6 and irisin. These proteins then travel through the bloodstream to reduce inflammation, improve insulin sensitivity, and even support brain repair. This piece illustrates how movement triggers a systemic healing cascade throughout the human body.

How does muscle memory work?

Muscle memory is less about remembering how to ride a bike and more about what's happening in muscle cells. Increasing the cells' size, say by working out, leads to an increase in nuclei, which increases the production of mitochondria. When your fitness regimen falls to the wayside and you decide to re-enter the gym, these gains-based nuclei are already present to quicken muscle cells' adaptation to exercise.

How does your body turn food into energy?

Cells get energy via a process known as cellular respiration, which involves turning glucose into ATP or adenosine triphosphate. Breaking the phosphate bonds of ATP results in usable energy being released into cells, which can then use that energy to power biological processes. This 10-minute video explains how glucose turns into ATP, giving the body the energy it needs to survive.

On average, the human body produces about 100 watts of electricity—enough to power a light bulb—but some people can produce over 2,000 watts in short bursts, such as when sprinting.

Coffee gives you energy, but it ultimately makes you more tired

The caffeine in coffee delays your brain's fatigue signals. Caffeine blocks adenosine, a compound that builds up as you burn energy and signals rest. Once caffeine wears off, adenosine floods back, leaving you even more tired.

Physiological muscle memory allows us to quickly regain lost musculature

The term "muscle memory" is most often associated with the neurological kind, which involves the development of strong and efficient neural pathways in the brain and spine. Physiological muscle memory also slows the loss of muscle mass, with both types affected by genetics and diet.

Using fitness wearables to track muscle wasting in astronauts

All that exercising, and astronauts still are likely to lose a large amount of muscle mass while in microgravity. Astronauts can lose up to 20 percent of their muscle in as little as five days in space. Currently, tracking muscle loss means waiting until astronauts land to remeasure their muscle density post-trip. This article explains a NASA-backed fitness wearable that may be able to track muscle atrophy as it happens.

Adults may lose roughly 3% of their muscle mass each decade after 30.

Muscular system explained

Skeletal, cardiac, and smooth muscles form the system that powers movement, survival, and daily life. Skeletal muscles are voluntary, enabling conscious actions like lifting or walking, while cardiac and smooth muscles are involuntary, controlled by the autonomic nervous system. From every heartbeat to each breath, these three muscle types work in harmony to keep you moving, thriving, and alive.

Metabolism, a collection of chemical reactions at the cellular level, processes food and converts it into energy to power the body.

Explore how excitatory cells, such as neurons and muscle cells, transmit information in the body via electrochemical signals, which can travel up to 120 meters (390 feet) per second.

Microgravity environments reduce muscle mass and bone density

Muscles that assist with balance and resistance to gravity are not subjected to their usual workload on the International Space Station. See the type of exercises that astronauts must complete for roughly two hours daily, and learn why these movements are necessary to preserve astronauts' muscles, bones, and cardiovascular health.

VO2 max measures the body's ability to use oxygen to produce energy

VO2 max is the maximum rate at which the body can use oxygen to aerobically produce energy—adenosine triphosphate—for use during intense exercise. Aerobic exercise increases VO2 max, counteracting age-related decline by increasing the body's capillary count and remodeling the heart's left ventricle, increasing the amount of blood it pumps.

How trauma gets ‘under the skin’

A study examining the muscle function of older adults who have at least one adverse childhood experience (ACE) suggests that trauma digs itself into muscle cells. Participants who reported childhood trauma were found to have lower maximum levels of cellular energy than people who reported fewer or no ACEs. Such compromised mitochondrial function "doesn't bode well," as it relates to a variety of health and age-related outcomes.

How ALS (Lou Gehrig's Disease) might work, and what scientists are learning about it

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects the nerve cells (neurons) controlling muscle movement. As the motor neurons degenerate, they stop sending signals to the muscles, causing progressive muscle weakness and, eventually, death. This three-minute animation focuses on the mechanisms within the motor neurons that cause them to degenerate. By understanding these mechanisms, researchers hope to one day find a cure for ALS.

The stages of fasting

What happens to the body when it goes without caloric intake? This article overviews the immediate physical effects of fasting. Within a day of going without food, the body will have used up its glucose stores and ordered the liver and muscles to convert their glycogen (glucose storage) into usable glucose. By the second day, glycogen stores will run out, forcing the body to use fat as energy. This process is known as ketosis.

What does the muscular system do?

The muscular system is responsible for movement by and throughout the body. Smooth muscle contractions push food and blood through the digestive tract and blood vessels, respectively. Skeletal muscles are responsible for voluntary movement or lack thereof by the body. Cardiac muscle controls the beating of the heart, which is the pump that powers the circulatory system responsible for distributing energy and nutrients to cells across the body.

Astronauts exercise on the International Space Station

Astronauts maintain bone, muscle, and cardiovascular health with physical activity. It's crucial that they make time to exercise for approximately two hours per day. This resource offers a behind-the-scenes look at how high-intensity workouts help prevent muscle atrophy, bone density loss, and aerobic decline during monthslong space missions.

What sleep loss does to the brain

Proteins in the brain perform various critical functions, such as helping neurotransmitters function or enabling electrical activity in the organ. These proteins must fold in specific ways to perform their duties, similar to paper airplanes. Sleep deprivation contributes to the gathering of misfolded proteins that aren't shaped correctly for their roles and so accumulate in undesired spaces, such as in the gaps between neurons.

'Viscoelasticity' allows muscles to be elongated briefly after stretching

The protective tissues around skeletal muscles consist of elastic proteins like collagen. Stretching them expands their length while retaining strength, ideal for athletes.

Exercise helps make your arteries more elastic.

The depression paradox refers to a lack of energy to take action to help alleviate it

Activities like exercise, even at low levels, have been shown to alleviate some of depression's symptoms for some people. However, depression saps energy levels, making it particularly difficult to motivate oneself to take helpful action.

Aging explained with Dr. Nick Golinvaux

Aging is more than wrinkles and gray hair—it’s a gradual decline in cellular function. Over time, DNA damage, telomere shortening, and mitochondrial inefficiency contribute to weaker bones, slower memory, and reduced vitality. While aging is inevitable, regular exercise, quality sleep, and stress management maintain health and extend one’s years.

What is the muscular system?

The muscular system comprises three distinct types of muscle: smooth, cardiac, and skeletal. Cardiac muscles make up the heart, whereas smooth and skeletal muscles are found throughout the body. Smooth muscles line blood vessels and most organs, and skeletal muscles are responsible for moving the body or holding it stationary. All muscles are made of muscle cells or fibers, which give them the ability to contract.

Stress-induced adrenaline can trigger a 'hysterical strength' response

The stress response is a powerful ancient mechanism designed to maximize human survival—it can even result in superhuman strength. The adrenal glands are located just above the kidneys, and stress-induced adrenaline release causes more blood (and therefore more oxygen) to flow to your muscles, increasing performance.

Fertilizers provide essential nutrients to plants for their growth, including nitrogen, phosphorus, and potassium, but an overabundance of these nutrients may also harm plants.

Exertional heatstroke is a leading cause of death among athletes and soldiers in training, and typically occurs when someone sweats intensely while exercising in the heat.

Even brief physical activity can trigger the release of neurotransmitters that provide mental health boosts.

How muscles get their names

There are more than 600 muscles that crisscross the human body, and each has a name that's more than a simple label. Muscle names also typically communicate the muscle's size, behavior, length, location, appearance, direction, and attachments to bone. These names usually have Greek or Latin roots, such as in the case of the deltoid muscles, which are named in reference to the Greek letter delta (𐤃).

World records are often broken later in the day—and scientists wonder if muscle clocks explain the difference.

Food passes through the digestive system via muscle movement known as peristalsis, a rippling contraction that pushes food onward through tubular organs.

Breaking down the challenges of alkaline environments and how extremophiles survive them

These areas are far less acidic than the interiors of most organisms' cells, and this imbalance draws protons that are needed for various metabolic processes, including energy production, out of cells. To counter these effects, some alkaliphiles have developed stronger proton regulation across their cellular membranes and proteins that drive these processes with greater stability amid such acidity imbalances.

What happens to your brain when you burn out?

You've probably heard of burnout, also known as the feeling of exhaustion that happens after a long period of being overwhelmed or stressed. It's often associated with work and careers, but other parts of life, like parenting, can cause burnout, too. Scientists are figuring out what happens, biochemically speaking, in the brain when burnout hits—and spoiler alert, it includes a neurotransmitter called glutamate. Watch this video to learn more.

The human brain only uses 5% more energy during active tasks versus resting

Despite only being 2% of the weight of a human body, the average adult brain consumes 20% of its energy, with the majority of it spent on maintaining homeostasis—the stable equilibrium conditions of temperature, acidity, blood sugar, and other properties in the body. For infants, the consumption is closer to 50%.

Endurance art strains and exhausts the body

Artists like Marina Abramović are known for testing the limits of human endurance. Endurance art can involve carrying heavy objects or posing uncomfortably for long durations. (This resource contains some artistic depictions of violence.)

Gradual chemical build-up reduces the effectiveness of rechargeable batteries

During charge cycles, small chemical deposits gradually form a film on the electrodes where they make contact with the electrolyte, trapping ions that would otherwise facilitate the flow of electricity. Mechanical degradation from electrode wear and electrical shorting from structural instability can also reduce battery capacity.

How skeletal and smooth muscles differ

Skeletal and smooth muscles are two of the three muscle types found throughout the body. The former is attached to bones via tendons, enables limb movement, and is consciously controlled. The latter is found lining blood vessels and hollow organs (e.g., the intestines, stomach, and esophagus) and is managed by the autonomic nervous system, which means it's outside conscious control.

Coffee is addictive, and those going through withdrawal often experience headaches and fatigue.

Stress activates the "fight-or-flight" response when we face threats, a reaction that can help keep us alive.

Explore how to safely start 'strengthmaxxing' with body weight—not actual weights.

Adults need 2 days of muscle-strengthening activity weekly—yet most of us aren't doing that.

Runners typically burn 2,600 calories during a marathon

They also burn between 5-10 pounds of water weight, often feel more focused and elated (thanks to increased neurotransmitters), and, oddly enough, temporarily grow about a half-inch shorter due to back muscles tensing.

Explore the abundance of different types of cells in the human body

Lacking a nucleus and other organelles to maximize space for oxygen-carrying hemoglobin and enhance maneuverability through narrow capillaries, there are about four times as many red blood cells and platelets as all other cell types in the body combined. However, about half of the body's cell biomass consists of skeletal myocytes, or muscle fibers.

Too little stress can also harm our health because mild or moderate stress—followed by recovery—helps make us resilient.

Aging results from the cumulative breakdown of cellular and tissue processes

A cumulative breakdown of cellular and tissue processes combines to result in decreased organ function, disrupting the systems driving normal human physiology. This five-minute video provides a primer on the subject, complete with a discussion of risk factors, cellular changes, and potential future treatments in the fight against aging.

The Greeks weightlifted using massive stones and admired strength—but they viewed muscles differently