High-powered red light therapy—delivered directly to nerve fibers via a fiber optic needle—has been used in recent experimental research to suppress pain.

Red light therapy—a treatment harnessing a specific form of energy that penetrates the top layers of skin—is marketed for skincare and wellness, but has its roots in NASA plant growth research.

This 1440 Original video dives into what the science says about phototherapy and its various potential applications.

NASA began investigating the healing properties of red light therapy in the 1980s, when researchers studying how LED lights could aid in photosynthesis noticed that their hands seemed to heal faster than normal under the lights.

Certain visible light therapies, when applied at specific intensities, can be used to treat skin conditions, including acne.

A 1974 Science News article proclaimed that within a decade, light therapy would be on par with traditional drugs.

The design of a psychiatric ward in Norway aims to integrate more circadian rhythm-friendly lights as part of its treatment protocols for conditions including psychosis, severe depression, and more.

Light therapy was widely used as a medical treatment for various maladies in the early 1900s before it was replaced by antibiotics.

See photos of ultraviolet light therapy, widely administered in the early 1900s, particularly among children with skin diseases, tuberculosis, rickets, and more.

In 2026, the US FDA approved a light-activated gel combined with red light therapy as a nonsurgical treatment option for the most common type of skin cancer.

Bright light therapy involves basking in 10,000 lux of light for 30 minutes each morning

Nothing is better than going outside and soaking up real sunlight. However, this is harder in winter, especially in very cold and cloudy regions. SAD lamps are designed to project 10,000 lux—a unit of illuminance, or how much light actually hits a surface (rather than how much is produced, like watts). This video discusses product options and practical considerations.

Bioluminescent reaction enzymes are often used in biomedical research

Near-infrared luciferase systems allow researchers to image and analyze cellular activity in living animals because they penetrate tissue more deeply than visible light. This provides a means of studying gene expression and protein interactions without harming the animals.

Scientists using gene therapy recently managed to regenerate retinal cells in the lab—a breakthrough for mammals that could potentially lead to future treatments for human retinal diseases.

Scientists create contact lenses that give you infrared vision

Scientists have created lenses that use nanoparticles to convert infrared light into visible light, allowing human eyes to observe previously invisible parts of the electromagnetic spectrum. This technology may help colorblind individuals by converting colors they cannot see into wavelengths they can.

Using brain implants to restore vision

Several companies are attempting to create brain-computer interfaces that skip over retinas and optic nerves to allow visual input to go straight to the brain, potentially restoring some sight to the blind. Clinical trial findings suggest restored sight is sparse and manifests differently than a sighted person might expect, appearing as specks of "light" clusters called phosphenes to help differentiate one's surroundings.

Biohacking to boost personal health has become a concept that encompasses everything from vitamin regimens and cryochambers to brain implants and red light therapy.

When processing light, the brain can perceive colors with no natural wavelength

While some animals are sensitive to many forms of light, humans possess receptors that are sensitive to red, green, and blue wavelengths. These receptors send signals to the brain, which are processed and mixed to produce the array of colors we observe, including magenta, pink, and "supercolors" that lack a corresponding natural wavelength in the visible spectrum.

Photodynamic therapy is one current treatment for age-related macular degeneration.

Blacklights can illuminate certain biological materials, including blood, teeth, and fingernails, because they contain fluorophores—molecules that visibly glow immediately after exposure to higher-energy light.

Proteins with limited light sensitivity prevent humans from seeing all types of light

Specialized photoreceptor cells in the retina called cones each possess photopigments that activate when exposed to three ranges of visible light. Other forms of electromagnetic radiation outside the activation range do not generate signals for processing in the brain, thereby limiting average human vision to approximately 10 million colors.

Some materials can absorb low-energy light and emit high-energy radiation

Through anti-Stokes cooling, incoming energy is combined with vibrations in a material's crystal lattice to produce a net reduction in its temperature. Using this effect, lasers can be directed at microchip hot spots to help keep data centers cool.

The origin of LASIK eye surgery, from a lab incident to federal funding and widespread use

After a University of Michigan engineering student suffered retinal burns from an ultrashort pulse laser, researchers realized it could be used to reshape the cornea and improve a person's vision with greater precision than a scalpel and earlier laser technologies. Agencies, including the National Science Foundation, the National Institutes of Health, and the Department of Energy, provided funding to develop and commercialize the procedure.

Infrared light is most often associated with thermal radiation and cooking food

Although extensively used in remote controls for electronics, where LED lights send signals wirelessly, infrared cameras allow for night vision and thermography—imaging of heat patterns in the body to non-invasively reveal blood flow for supplementary diagnostics. Infrared radiation also provides heat in toasters, saunas, and other technologies.

Imagining if humans could perform photosynthesis and how it would change our anatomy

Since chloroplasts reflect green light, becoming photosynthetic would give our skin a green appearance. Because photosynthesis has efficiencies of only 5% to 9%, and humans burn 2,000 Calories daily compared to about 200 burned by a tree, becoming photosynthetic would also require us to adopt a less active, sun-filled lifestyle.

Virtually all plants are biofluorescent because their photosynthesis is powered by chlorophyll, a pigment that glows red as a way to get rid of excess energy when exposed to ultraviolet light.

Restoring vision in impaired patients via CRISPR

Since CRISPR was revealed as a gene editing tool in 2012, it has been on an accelerated track to real-world applications. Among other clinical demonstrations, doctors have now injected a CRISPR treatment directly into eye cells, helping vision-impaired patients see shapes and colors again.

Vision experts generally don't recommend blue-light-blocking glasses because there's no scientific evidence that the light from computer screens damages eyes.

Bioluminescence may provide a sustainable alternative to electric lighting

French start-up Glowee is experimenting with lights made from bioluminescent microorganisms in public spaces to reduce energy use. While the technology shows promise, challenges remain with brightness, maintenance, and scaling it for widespread use.

How the buildings you occupy may affect your brain health

Beautiful spaces filled with light and natural motifs aren't just aesthetic, but likely key to your health. Researchers had study participants view photographs of two distinct buildings, one designed with more natural elements while the other featured more abstract shapes and lines. Using electroencephalograph readings of each participant, they discovered participants had less brain inflammation while viewing the "biophilic," or natural, architecture. Learn more about the interdisciplinary framework of so-called neuroarchitecture here.

Stem cell therapies

Stem cells' special attributes interest researchers developing new therapeutic tools for a variety of health problems. Much of this research is done with support from the National Institutes of Health (NIH). This page offers a snapshot of research programs funded by the NIH and the health problems those programs focus on.

Laser technology powers communication, medical and manufacturing tools

Lasers are used when scanning groceries, printing documents or undergoing cosmetic procedures to enhance efficiency, precision and accuracy. Missile defense, targeting and optical communication systems have made using laser technology habitual in the military.

Jaundice, which can make the skin and eyes appear yellow, is a buildup of bilirubin, a waste product that forms when old red blood cells break down.

The weakest form of light that is dangerous to humans is ultraviolet

Unlike radio waves, microwave, infrared, and visible light, UV light can produce chemical changes, such as curing adhesives and resins, causing substances to fluoresce, and destroying the genetic material of microorganisms. This makes UV light useful for sterilization, forensics, and quickly drying nail polish.

Remylination is a huge focus for treatment—especially among older adults

Our ability to build new myelin sheaths for nerves degrades with age. There have been research advances boosting cells that support these processes and clear away debris from degraded myelin, but not yet any medications to boost myelination itself, which would aid nerve signaling and preserve nerve function.

Radio waves are used in broadcasting, weather radar, telecommunications, and GPS

Its ability to bend around obstacles and reflect off the ionosphere—an electrified layer of Earth's upper atmosphere—allows this type of light to travel long distances without damaging living things due to its low energy. MRI scanners, WiFi, and Bluetooth technologies are also applications of this form of light.

Researchers have investigated the benefits of extreme pain rituals, exploring how and why we engage in these events when humans generally naturally avoid pain and perceive it as a negative experience.

Can microdosing improve mental health?

Animal studies involving microdoses of psilocybin, the psychoactive component in magic mushrooms and ketamine, found it helped to alleviate anxiety and inflammation, an immune response that can cause damage when chronically active. Human studies are ongoing. In at least one double-blind study, where researchers and patients don't know who got a placebo versus the real thing, about half of the participants incorrectly guessed they had been given placebos.

Random lasers can be created from biomaterials, such as peanuts and birch leaves

Rather than creating a narrow beam of light via amplification in an optical cavity, the random laser produces a red glow by scattering photons created in the natural pores of a peanut kernel after it has been injected with a solution of light-generating carbon dots derived from birch leaves.

Read Norman Rosenthal’s original 1984 paper describing SAD

The study helped formalize research and diagnosis of seasonal affective disorder, catalyzing the development of therapies (like bright light) and leading to broader adoption of effective treatments. It also helped connect the influence of light and seasons on biological mechanisms in the human body, spurring exploration of circadian rhythms.

One theory claims the retinae of SAD patients may fail to adjust to less light in winter

Most people’s eyes become more sensitive to light in the winter months, but some do not. This failure to adjust causes ripple effects on those individuals’ biological clocks. This Ted-ED video provides a clear, brief, narrative explanation of the condition in six minutes.

Psychedelic side effects, including worsening mental health for some patients, give pause

This article explores whether the therapeutic potential of psychedelic drug use is really as good as current research suggests. Scientists are exploring its applications for conditions ranging from the existential crisis that can accompany terminal diagnoses to chronic mental health conditions, including anxiety and PTSD.

The commercial and therapeutic potential of psychedelics

A 2006 study into the potential therapeutic benefits of psychedelics sparked a renewed interest in the field of psychedelic research, a development that has cascaded into commercialized ventures and experiences. This article details how growing research into the psychological benefits of psychedelics is matched by the rise of anecdotal reports, book deals, businesses, and corporate claims seeking to capitalize on psychedelic potential.

Neural interfaces offer major medical potential but raise serious ethical concerns

Although brain-computer interfaces can help people recover lost functions and allow direct brain-to-computer communication in the future, surveys have shown little public support for using them to boost abilities like memory or focus in healthy people.

The chlorophyll in plants captures energy in the form of red and blue light

Light-dependent reactions during photosynthesis convert sunlight into chemical energy, stored within the bonds of molecules such as ATP and NADPH. Rather than being absorbed for these reactions, most green light is reflected, causing most plants to appear green.

Starting with red, colorful objects will appear to lose their colors the deeper they are submerged because water scatters light, reducing the amount available to reflect off objects and be observed.

The neurobiology of meaningfulness: the benefits of psychedelics

Psychedelics produce powerful emotions in its users, including a profound sense of meaningfulness. The philosopher William James called this sense "noetic" in the late 19th century, but for decades researchers avoided studying the effects of such drugs on the brain. However, the recent resurgence in psychedelic research has heightened interest in the relationship between this noetic sense resulting from the therapeutic use of drugs. Learn what researchers have found out here.

How psychedelics can potentially reinvent learning

Critical periods, discovered in the early 20th century, describe a period when someone is incredibly sensitive to their environment, and any information learned can stick with them for life. Some researchers argue these states can be "reopened" via psychedelics, which put the mind into a malleable state that can potentially be used to treat conditions ranging from lazy eyes to PTSD.

Solar sails use light as a means of propulsion

Photons possess momentum and can transfer it to objects they strike or bounce off, imparting radiative pressure, or a light-based force over a small surface area. Lasers fired at observational equipment with specially designed sails can theoretically use this mechanism to accelerate up to 20% the speed of light.

'Magic ink' is redefining the tattoo

One University of Colorado professor has developed an ink that can be "turned on" with exposure to UV light, and "turned off" with sunlight. While the ink could help those who want to hide their body art from family members or coworkers, there are potential uses for medical procedures.

View the electromagnetic spectrum and the properties of different types of light

All forms of electromagnetic radiation, from radio waves to gamma rays, travel at the speed of light in a vacuum, but their wavelengths decrease as their frequencies increase. The light-sensitive nerve cells in the human eye are sensitive to a narrow range of values, which we observe as the spectrum of visible light.

Stimulating electrons to emit identical photons produces lasers

This effect was predicted by Albert Einstein in 1917, and requires all excited electrons in a material to exist in the same excited metastable state within their atoms. Pumping all atoms through the same mechanism, such as electricity or flash lamps, can create this environment.