Watch a crystal undergo X-ray diffraction to determine its internal geometry

X-ray diffraction reveals atomic structures by analyzing how crystals scatter X-rays

X-ray diffraction involves rotating a crystal in an X-ray beam while a detector captures the resulting diffraction patterns, which depend on the crystal’s internal structure. The mathematical principles behind the technique won the 1915 Nobel Prize and improved crystallography.

Explore a 3D model of the experimental setup Rosalind Franklin used to take Photo 51

To capture the X-ray diffraction image of DNA from the thymus of a calf, Franklin built a humidity-controlling camera to isolate the B form of DNA. The exposure lasted 60 hours and produced a cross pattern, indicating a helical structure.

Photo 51's distinct 'X' pattern and spacing provided data to validate DNA's model

Rosalind Franklin and Raymond Gosling captured the photo after bombarding DNA fibers with X-rays and observing how the beams were deflected. The photo had a 62-hour exposure time and indicated a helical structure for DNA.

Scientists can create movies of atomic and molecular phenomena using X-ray free-electron lasers, in which images are produced by matter being struck by high-intensity light created by accelerating electrons.

In an X-ray free-electron laser, electromagnetic fields are used to accelerate and move electrons in wiggling patterns, causing them to emit synchronized, high-energy X-rays. This resulting light beam can strike targets up to 120 times per second to create movies of changing molecular structures and phenomena.

Time crystals are systems of atoms organized into periodic patterns of motion

Unlike traditional crystals—whose atomic structures cause them to look identical no matter how you look at them in space—time crystals exhibit this behavior through time, where the motion of atoms will bring them to the same positions relative to one another regularly.

Particle accelerators have been used to reveal detailed ant anatomy

Using a synchrotron facility at the Karlsruhe Institute of Technology in Germany, a pair of X-ray beams swept across about 2,200 ant specimens to create over 200 terabytes of projection images from multiple angles. The images were compiled into micrometer-resolution 3D reconstructions of 792 species, which are freely accessible on the Antscan platform.

X-ray data from Rosalind Franklin was key to discovering DNA’s double-helix structure

Although unpublished, the data reached James Watson and Francis Crick, who worked at another institution. Incorporating her data allowed them to validate their model of DNA, which they published without crediting her.

As crystals form, their properties and the shapes they take on, including cubic, tetragonal, and hexagonal patterns, reflect the arrangement of their constituent atoms.

Rosalind Franklin’s work led to Nobel Prize-winning discoveries in DNA and virology

Her X-ray diffraction imaging helped uncover the structure of DNA, which earned James Watson, Francis Crick, and Maurice Wilkins a Nobel Prize. The same techniques enabled virus imaging, contributing to Aaron Klug's Nobel Prize in chemistry.

X-rays earned the very first Nobel Prize in physics for revealing hidden worlds

In 1895, Wilhelm Conrad Röntgen discovered X-rays, which could pass through solid objects and make unseen structures visible. Today’s X-ray tools continue to advance science and medicine, including capturing real-time images of proteins.

Computed tomography scans use X-rays to create 3D internal images

Just as shadows can reveal the shape of obstacles blocking visible light, the donut-shaped CT scanner measures how X-rays are blocked, revealing the shape of bones, organs, tissue, and other matter along a cross-section. As it rotates, the scanner combines these cross-sections to build a model of the internal structure.

Watson and Crick revealed DNA's double-helix structure using others' key findings

Their 1953 model, made from cardboard cutouts, explained how DNA stores genetic information through base pairing. Rather than experimenting and collecting their own data, they incorporated patterns and data from other scientists through trial and error.

Rosalind Franklin was the long-overlooked contributor to discovering DNA's structure

Though James Watson, Francis Crick, and Maurice Wilkins are credited with discovering the DNA double helix, it incorporated Rosalind Franklin's unpublished data. Photo 51, her famous DNA image, took more than 100 hours to produce and a year’s worth of analysis to interpret.

Watch the motion of an individual photon using a high-speed camera

Although light travels over 3 million football fields per second, cameras that capture trillions of frames per second can observe individual particles of light as they interact with atoms in materials they travel through. Such observations can be used to determine the speed of light in different materials.

Airport security scanners use X-rays to infer baggage contents, with newer machines combining images taken at multiple angles and with various X-ray energies for improved threat detection.

Synchrotron radiation has revealed the fur color of creatures millions of years old

When electrons are accelerated in the loop, they produce intense X-rays that can reveal properties of a sample struck by them, just as X-rays can be used to show bone structure in humans. Studying the reflected light from fossils can uncover the presence of known pigmentation compounds.

Astronauts have used a small portable device to take the first-ever X-rays in space, opening the door for new opportunities for aerospace medicine.

Take a 360-degree look at biochemical activity from within a human cell

In this tour, users can observe the dynamic processes that occur within the basic units of the human body, including the production and transport of proteins and the assembly and disassembly of microtubules—thin, cylindrical structures that provide structural support and a means of moving material within the cell.

Genomic sequencing is the process of determining the order of nucleotides that make up an organism's genetic information and can be done in about 24 hours or less for human DNA.

View 3D renderings of atomic orbitals created with quantum mechanics

Scientists use the Schrödinger equation to determine how a system governed by a wavefunction—an equation that predicts the probability of certain outcomes—evolves with time. Computers can animate atomic structure and behavior by depicting the wavefunction as a fluid that guides a particle, like water moving a speck of dust.

Flip through centuries-old artifacts in this 3D library

Archaeology is hands-on work, giving researchers the ability to analyze artifacts from as many sides as possible to find marks left by those that came before us. While looking at pictures of artifacts gives you some insight, you're limited to...

Glowing chemicals allow scientists to read DNA like a barcode

The process of determining the order of nitrogenous bases in DNA involves first cutting the DNA into fragments, which are duplicated multiple times using bacteria. Fluorescently labeled terminator bases are added to fragments, which are sorted by length and read via laser to reconstruct the sequence.

Watch how DNA is packaged to a 10,000th of its original size in a cell

In humans, the 2-meter (6.56-foot) molecule wraps around spool-like proteins called histones, forming beads—nucleosomes—that fold up into fibers. These fibers—chromatin—form loops through folding that compress into larger fibers, which tightly coil together to form a chromosome.

A particle accelerator allowed researchers to noninvasively examine a mummy

The mummy hailed from the Faiyum oasis, where Egyptian and Roman cultures intersected, and was analyzed using the Advanced Photon Source at Argonne National Laboratory. The device used high-energy X-rays to probe the material composition of numerous objects embedded deep inside the mummy without damaging its remains.

Scientists can determine the age of rocks, fossils, and other ancient samples by measuring how many radioactive atoms in the sample have decayed, a process that occurs at precise, well-known rates.

How do you sequence a genome?

If the genome is made up of microscopic chromosomes, how do scientists actually sequence it? Here's a 5-minute video explaining one of the most common processes.

The Curies developed a way to measure radioactivity in an old medical dissecting room

Despite lacking proper laboratory conditions, Marie and Pierre built an ionization chamber and a piezoelectric quartz electrometer to measure the amount of charged particles released by radiation, with a sensitivity of ten-trillionth of an ampere. Substances with different emission rates indicated different elements.

Explore 3D models of some of the most dangerous viruses, allowing us to understand these and other pathogens in new ways.

Visualization of printing synthetic DNA

Ever wonder how synthetic DNA is made? Discover how GenScript uses innovative technology to synthesize precise, high-quality DNA at a larger scale than ever before.

What do archaeologists actually do?

Movies and other media show them digging a bit, maybe fighting off artifact smugglers, but what archaeologists actually do? Using a variety of tools and sciences, archaeologists are able to get a glimpse into humanity's past. This article explains what work is like for everyday archaeologists.

DNA computing allows for storage and processing of massive amounts of data

Although costly and less efficient for simpler tasks, as of 2025, DNA could hold 455 exabytes of data with near limitless parallel computation potential in small data centers. Every movie ever made would fit inside the volume of a single sugar cube.

The secret lives of cells

Cutting-edge microscopy has revealed previously unseen interactions of biological molecules within their cellular environment, enabling scientists to observe and analyze the molecules in a holistic view. This podcast explains the minute advancements made over the last few decades in observing cells, revealing how scientists have come and what the future holds for the field.

In Raman spectroscopy, molecules use some of the energy from incoming light to shift into a more energetic vibration and scatter the remaining light, which scientists can use to confirm the molecule's presence.

Mechanical watches measure the passage of time via the vibration of a quartz crystal

When electricity from a battery passes through the crystal inside a watch, the crystal vibrates, creating an electrical signal with a precise frequency of one vibration per second. This signal moves the hand of the watch so that it ticks once per second, allowing it to track the passage of time.

Diamonds have been made from substances such as peanut butter and carbon dioxide, though they can be created from any carbon-rich material under extreme pressure and temperature.

Rocks, crystals, and gemstones are all made of minerals—solids that form from natural processes, such as evaporated water leaving salt behind or lava rapidly cooling into a solid.

Explore human anatomy with these beautiful images

The Human Organ Atlas offers detailed 3D images of dozens of human organs. It was created with very bright X-rays from a particle accelerator, which is formally called a synchroton imaging method.

The history of chemistry up to World War I, from alchemists seeking gold to probing atomic structure

Those involved in the predecessor of the modern scientific discipline engaged in experimentation to develop recipes that would transform ordinary matter into gold and to create medicines, cosmetics, dyes, and alloys. Over the course of centuries, scientists identified unique elements, organized them based on their properties in the periodic table, and eventually developed the technology to discover the internal structure of atoms.

Rather than measuring the rising and falling of the sun or pendulum swings, optical clocks track the passage of time using the extremely consistent vibrations of atoms.

The frequency of visible light is significantly greater than that of microwaves used in cesium atomic clocks. This makes optical clocks about 100 times more accurate, losing at most one second across the entire age of the universe.

How scientists determine elemental composition based on the light emitted by cooling atoms

When electrons within an atom drop to a lower energy level closer to the nucleus, they lose energy and produce light with energy equal to the difference between the two energy levels. Because these levels and the corresponding emitted light are unique to each element, the light serves as a unique signature that can be compared to known lab samples for identification.

View a gallery of diatoms—algae surrounded by glass-like shells—captured via microscope.

Cells modify their internal spacing to improve biochemical reaction efficiencies

Studies involving microscopy and genetic engineering tools in yeast and human cells show ribosomes act as crowding agents—much like packing peanuts—and their concentrations are actively tuned to alter the rate of cellular functions. However, these concentrations and cell crowding levels vary across different tissues and cell types.

Scientists can tag distinct proteins with fluorescent probes that emit different colors, allowing them to visualize multiple biochemical processes simultaneously.

Particle detection has evolved from cloud and bubble chambers to digital 3D displays

As invisible particles passed through cloud and bubble chambers, they disrupted supersaturated vapor and superheated liquid, respectively, creating trails that served as proxies for cosmic rays. The transition from photographed events to digital sensors enhanced data collection and accuracy.

The twenty-year effort to design the Webb's optics

Since its located 1 million miles from Earth, the Webb space observatory has to be able to repair itself—no Space Shuttles can be dispatched with astronaut engineers to repair it. That's why over two decades teams reiterated, cross-checked, and hyper-optimized the Webb's observing surface. Their efforts produced the world's largest space-based optical surface that is peering billions of years back in time. Learn the wild engineering of the telescope here.

Chromium contaminants in a ruby crystal gave the world's first laser its red color

The red light originates from a long-lasting excited electron state in the element's atomic structure. The brittle gray metal has historically been used in pigment production, the manufacturing of rust-resistant stainless steel, and the creation of durable coatings with long-lasting shine for metals, wood, and leather.

View the fluorescently stained internal structures of a tardigrade

The photograph won the Olympus Global Life Science Light Microscopy Americas regional award in 2019. Using chemicals from biofluorescent organisms, the image illuminates internal structures with multiple hues in an otherwise mostly colorless organism.

Play a game that reveals if investors with a crystal ball make better trades

The "crystal ball" game reveals how well you would do trading stocks and bonds if you could see the front page of the Wall Street Journal one day in advance.

Explore the efficiency of photosynthesis under various conditions

In this simulation, users can track how the cellular concentrations of ATP, NADPH, glucose, and oxygen vary over time in response to changes in temperature, acidity, carbon dioxide concentration, and the properties of incoming light. Through multiple trials, users can identify the optimal conditions for photosynthetic reactions.

The new phenomenon of 15-minute lab-grown diamonds

In 2024, scientists developed a groundbreaking method to create diamonds at normal room temperature and pressure. This efficient and simple process contrasts with the traditional high-pressure, high-temperature method. While limitations still exist, such as minuscule sizes, this discovery moves us toward an exciting new era in diamond synthesis. Check out the article for further information about how diamonds are made.