View the industrial applications of extremozymes, from food safety to antibiotic production

An overview of extremophiles and the biochemical adaptations employed by various types

These organisms thrive in environments that would normally be inhospitable to most living things by using molecules that help counter deadly environmental factors. These include antifreeze-like proteins that prevent psychrophiles from freezing and rupturing in polar regions, and osmoprotectants that prevent some extremophiles from losing water to salty environments.

Why extremophiles may play an important role in terraforming Mars

Possessing unique biochemicals that can detoxify extreme environments and resilience against the Martian surface that is lethal to humans, scientists are exploring whether colonies of these organisms can transform small areas of the Red Planet into future habitats for humans. Extremophiles may also be best equipped to serve as microscopic factories for the fabrication of essential polymers.

The adaptations of metallophiles and how they can be harnessed for bioremediation

These extremophiles have adapted to biomes with very high concentrations of metals and toxic chemicals by developing mechanisms to isolate these substances within cellular compartments and break them down into less harmful forms with specialized proteins. They have the potential to support the decontamination of metal-rich wastewater and soil, as well as the extraction of rare-earth metals.

Breaking down the challenges of alkaline environments and how extremophiles survive them

These areas are far less acidic than the interiors of most organisms' cells, and this imbalance draws protons that are needed for various metabolic processes, including energy production, out of cells. To counter these effects, some alkaliphiles have developed stronger proton regulation across their cellular membranes and proteins that drive these processes with greater stability amid such acidity imbalances.

Extremophiles were likely to have been Earth's first, and are expected to be its last, organisms

Their ability to survive in an enormous range of environmental conditions, including some resembling what has been modeled to have existed relatively shortly after Earth's formation, makes them the leading candidates for enduring the increasing solar intensity and the subsequent effects (e.g., zero-oxygen atmosphere, evaporated oceans) expected in the coming billions of years.

Read a technical review of extremophile categories, including the habitats of each

Acidophiles can survive in environments with acidity greater than that of the human stomach, and some radiophiles can live in places with radiation exposure hundreds of times higher than what is lethal to humans. Piezophiles—formerly known as barophiles—have been found in the Mariana Trench, where pressures are over 1,000 times larger than those on Earth's surface.

The discovery of the first extremophile and how it revolutionized DNA analysis

While investigating samples taken from within and around the hot springs at Yellowstone National Park, microbiologist Thomas Brock discovered Thermus aquaticus, a microorganism that thrived in hot water. It contained an enzyme called Taq polymerase, a critical molecule in polymerase chain reaction—a molecular photocopier that amplifies genetic signals to improve medical diagnostics.

Learn how environmental conditions are optimized to increase bioremediation efficacy

Through biostimulation, Indigenous microbes are provided with moisture, nutrients, or oxygen to prevent their death and ensure optimal progression of their biochemical reactions. Bioaugmentation can introduce new microbial cultures to target specific compounds not natively found in the environment, while landfarming can spread or aerate contaminated soil to improve access to contaminants.

How scientists are using molecules found in acidophiles to develop new medical treatments

The Berkeley Pit, an open-pit copper mine in Butte, Montana, that ceased operations in 1982 and is now filled with highly acidic water, is home to various species of fungi and yeast. These extremophiles produce unique compounds that may have anti-inflammatory benefits and have already been used to create an antibiotic for staph infections.

Why the existence of extremophiles greatly improves the odds of life beyond Earth

The conditions for life have long been thought to include liquid water, an energy source, and the essential elements for organic molecules within environments on or near Earth's surface. However, because extremophiles thrive in far more inhospitable environments, astronomers now analyze exoplanets whose characteristics indicate environments that fall within a broader range of possibilities when searching for signs of extraterrestrial life.

Making industrial chemicals with synthetic biology

A new report forecasts that synthetic biology will transform from creating niche, environmentally friendly products to creating new molecules within the next decade.

Why bacterial bioremediation may help counter the negative effects of past chemical solutions

Molecules such as DDT, a synthetic insecticide, and PFAS—"forever" chemicals used to make products resistant to heat, water, and grease—have historically been used across various industries but are now known to be harmful. Microbes that can convert some of these substances into nontoxic products, such as water and carbon dioxide, have already been identified, with ongoing research to find others.

Most plastics are not biodegradable because breaking their chemical bonds requires temperatures lethal to most microbes, and these organisms have not been exposed to plastic long enough to evolve the necessary enzymes.

Learn about endoliths, the polyextremophiles that thrive inside rocks

These organisms include species that live in Antarctica, where they perform photosynthesis using light and water that makes it through pores in sandstone. Others residing in Earth's crust can survive temperatures reaching 60 degrees Celsius (140 degrees Fahrenheit) while generating energy through chemical reactions involving nutrients and gases trapped in rocks.

The risks of bioremediation, from intermediate products to ecological disruption

A step in the series of complex biochemical reactions involved in the implemented bioremediation process may produce dangerous molecules—sometimes more toxic than the initial pollutants—that require ongoing monitoring to ensure optimal conditions for processing these intermediates toward the eventual, safe outputs. Introducing non-native nutrients or species, including GMOs, may alter existing food webs and gene pools.

Recombinant DNA technology turns microorganisms into protein factories

Genes for molecules such as insulin can be inserted into loops of bacterial DNA called plasmids and reinserted into bacteria. Once placed in fermentation tanks, these bacteria use the gene to produce these molecules, which are then harvested and purified for eventual use.

Examining the potential of the emerging field of insect-based bioremediation

Also known as entomoremediation, the novel approach uses larvae and adult insects, including their gut microbiomes and associated enzymes, to extract or degrade pollutants. As of 2025, research has shown that black soldier flies can degrade a wide range of antibiotics, highlighting their potential for bioremediating antibiotic-contaminated organic waste.

View thermophiles found in Hot Springs National Park, including nanobacteria and ostracods

Most organisms in this subset of extremophiles live at temperatures between 60 and 80 degrees Celsius (140 to 176 degrees Fahrenheit), which is hot enough to unfold proteins needed for most biochemical reactions. In thermophiles, these molecules, including those needed to replicate DNA during cellular division, are tightly packed and held by stronger bonds to resist changes in shape.

How a polluted New York City waterway created extremophiles hungry for 'black mayonnaise'

In the 19th century, coal processing plants, oil refineries, a tannery, and other industries lining the Gowanus Canal contaminated its waters with coal tar, sewage, and other pollutants, forming the toxic sludge. Samples taken from the site before clean-up efforts revealed over 450 species of microbes with metabolisms adapted to break down these contaminants.

Challenges for synthetic biology

Can engineering approaches tame the complexity and unpredictability of living systems? An exploration of five challenges for the field and how they might be resolved.

Some marine life can survive the extreme pressure of the deep ocean because of specialized molecules that strengthen proteins, enzymes, and cellular membranes.

A look at hydrothermal vents, where barophiles and hyperthermophiles survive boiling water

Discovered in 1977 during an exploration of the Galapagos Rift, these seafloor openings spew hot magma and chemicals that heat seawater to hundreds of degrees. Without the sunlight found at depths of less than 1,000 meters (3,281 feet), extremophiles in these environments convert released chemicals into energy to survive, alongside surviving extreme pressures.

Bacteriophages—viruses that infect bacteria before multiplying within them—exist on Earth in numbers greater than all other living organisms combined.

Scientists from the frontline discuss the future of antibiotics and superbugs

Superbugs are a very real problem, but researchers around the world are working to advance our understanding of these pathogens and develop new medicines. This podcast talks with several scientists on the frontier of superbug research, offering insight into what we know—and what the future of medicine may look like.

How the US Department of Energy facilitated bioremediation with emulsified soybean oil

At sites where soil and groundwater were identified as contaminated with volatile organic compounds, scientists and engineers at the Office of Legacy Management used microbes to safely clean them up without more invasive methods, such as pump-and-treat. Treatment zones created at one location by injecting oil to help microbes spread quickly.

Meet six commercially available synbio products

An article exploring the science behind synbio products currently on the market, and projecting the products that can be expected over the next 10 years.

How microbes limited the damage and helped clean up the Deepwater Horizon oil spill

A bloom estimated to contain about 100 sextillion microbial cells broke down much of the 4.1 million barrels of spilled crude oil into nontoxic compounds in what was one of the most significant bioremediations of a human-made disaster. The microbes involved acted similarly to the first patented genetically modified organism in US history: an oil-eating bacterium engineered in 1971.

Synthetic biology can prevent extinction by creating create disease-resilient plants and animals

Through gene editing and the deployment of artificial cells, scientists can leverage learnings from the genetic sequencing of animals with known resistances to protect endangered species. Gene editing of certain species, such as mosquitoes, can also reduce their ability to spread diseases like malaria between humans.

Superbugs evolve defenses against medication, then share them with neighbors

One reason antibiotic resistance spreads so quickly is that bacteria have multiple mechanisms allowing them to share genetic material. This short video offers a concise explanation for each of these mechanisms, and animation that helps viewers understand how antimicrobial resistance can quickly spread from one organism to another.

Roughly 80% of US antibiotics sold each year go to agricultural use

Antibiotics have long been used in agriculture to treat diseases in animals and plants. However, antibiotics are also often misused, to treat non-bacterial diseases, to encourage growth in animals, and more. This expansive use of antibiotics has become one of the primary sources of the emergence of new superbugs.

Although PFAS, or forever chemicals, are intentionally designed to be extremely stable and long-lasting because of their strong carbon-fluorine bonds, these bonds can be broken by heat, plasma, and supercritical water.

Genetic engineering has accelerated millennia of altering various crops' genes

Although farmers have long cross-bred crops to obtain plants with specific colors, sizes, and other characteristics, these processes took significant time. Today, genetic modification in agriculture involves scientists altering an organism's DNA for various purposes, including enhancing pathogen resistance, removing allergens, and delaying spoilage.

Oxford scientists turned Fleming’s mold discovery into medicine

In 1939, a team at Oxford—including Howard Florey, Ernst Chain, and Norman Heatley—revived Fleming’s forgotten discovery. Using makeshift equipment like bedpans and milk churns, they purified enough penicillin to prove it could treat deadly infections.

How MIT researchers have used genetic mutations to improve photosynthesis efficiency

Recognizing that RuBisCO—a protein that binds carbon dioxide to other compounds to produce the building blocks of organic molecules—often mistakenly binds oxygen, scientists performed directed evolution experiments to modify the geometry of a bacterial version of the protein to cause it to preferentially interact with carbon dioxide over oxygen.

Synthetic biology transforms cells into custom DNA foundries

At companies like Ginkgo Bioworks, researchers are reprogramming cells to act as workshops that can create custom molecules, such as medicines and fertilizers, by stitching together DNA sequences—often in novel combinations—before inserting them into an organism's genome.

Bioluminescent reaction enzymes are often used in biomedical research

Near-infrared luciferase systems allow researchers to image and analyze cellular activity in living animals because they penetrate tissue more deeply than visible light. This provides a means of studying gene expression and protein interactions without harming the animals.

View a breakdown of bioremediation strategies, divided into onsite and offsite options

Depending on the contamination's complexity, in situ—onsite—options may be preferred and can include supplying oxygen or nutrients into the existing soil to accelerate the microbial breakdown already present in the environment. Ex-situ methods instead displace contamination for treatment away from the environment and may be used for volatile chemicals that require isolation, though this displacement can also spread contaminants if spilled.

How spoiled meat helped uncover a bacterium that can survive the vacuum of space

When a can of ground beef and pork spoiled despite attempts to sterilize it with gamma radiation, researcher Arthur Anderson isolated the bacteria in the food and discovered Deinococcus radiodurans. The polyextremophile has since been found on the walls of nuclear reactors and overcomes radiation damage through highly optimized DNA repair mechanisms.

An overview of bioremediation, which can help clean up oil spills, mining waste, and some plastics

The umbrella term refers to a variety of techniques that use organisms to remove harmful substances from an environment or break them down into nontoxic compounds. Because the availability of certain resources can limit the growth of these organisms and impair bioremediation efforts, nutrients such as fertilizers can be deployed to accelerate cleanup.

How artificial photosynthesis can help make plastics and fuels using sunlight

These systems link a molecular light absorber to a catalyst that can synthesize fuels—such as ethanol—and ethylene, a precursor to plastics, in a carbon-neutral manner. Because these byproducts have greater energy concentrations than the carbohydrates produced by photosynthetic organisms, research is ongoing to engineer the necessary catalysts.

The new antibiotic killing drug-resistant bacteria

A new class of antibiotics had not been discovered in more than 50 years—until late 2023, when MIT researchers announced a new antibiotic called Zosurabalpin. In animal testing, Zosurabalpin was able to treat at least one type of superbug. While the drug still needs to go through clinical trials, it is a significant advance at a time when new antibiotics are in great demand.

How the Supreme Court established biotechnology patent law with an oil-eating microbe

While working at General Electric, microbiologist Ananda Chakrabarty engineered a strain of Pseudomonas that could break down multiple types of hydrocarbons and filed a patent on the bioremediation organism. Despite challenges over whether living things could be patented, the 5-4 decision held that genetically modified organisms could be patented because they were human-made inventions.

Long-term evolution experiments use microbe's short generations to speed up selection

With quick generations of microbes, scientists can speed up the evolutionary process, with projects like the LTEE in California running for 40 years and generating 80,000 generations of E. coli.

The 'Penicillin Girls' made mass production possible

In Oxford during the early 1940s, six female technicians—later dubbed the “Penicillin Girls”—worked long hours tending mold cultures and extracting tiny amounts of penicillin.

Bacteria rapidly evolve (and share) new defenses against drugs they encounter

Unlike humans, bacteria rapidly make genetic changes in response to their environment, including creating defense against antibiotics. Furthermore, these defenses are passed on to their future generations and can even be shared with neighboring bacteria through horizontal gene transfer.

Biotech is trying to boost drug production efficiency—using chicken eggs

A company called Neion Bio is genetically engineering birds in a bid to produce medical compounds, a herculean task that scientists have struggled with for decades. The US FDA has approved only one chicken-derived drug in the past—an expensive treatment for a rare liver disorder. (Some users may encounter a paywall.)

Superbugs are pathogens that have proved resistant to medications designed to combat them, rendering standard treatments ineffective.

Solutions of bioluminescent bacteria can create FOMO-inducing living art

A 2002 exhibition at Montana State University-Bozeman placed the bacteria onto petri dishes that served as macroscopic pixels to create images. Once the bacteria finished eating all the food in the sealed dishes, the light slowly faded away, ending the exhibit.

Women's wartime suit features silk dyed with CRISPR-modified bacteria

Anna Dumitriu's bioart piece was created to commemorate the 75th anniversary of the first use of penicillin in a human patient and intends to raise awareness about the rapid development of antibiotic-resistant pathogens by using bacteria that have essentially been transformed into their pre-antibiotic era state.

Research on bacterial cultures used in yogurt production led to CRISPR's discovery

Scientists learned it was a microbial immune system that could be repurposed to protect dairy cultures from viruses. Today, nearly all yogurt is made with CRISPRized bacteria, as are genetically modified crops like herbicide-resistant corn, wheat, and soy.